Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia.
Daniel G. Chain,Andrea Casadio,Samuel Schacher,Ashok N. Hegde,Mireille Valbrun,Naoki Yamamoto,Alfred L. Goldberg,Dusan Bartsch,Eric R. Kandel,James H. Schwartz +9 more
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The formation of a persistently active cAMP-dependent protein kinase (PKA) is critical for establishing long-term synaptic facilitation (LTF) in Aplysia and appears to be a key function of proteasomes in LTF.About:
This article is published in Neuron.The article was published on 1999-01-01 and is currently open access. It has received 184 citations till now. The article focuses on the topics: Lactacystin & Protein kinase A.read more
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The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TL;DR: This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Journal ArticleDOI
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
TL;DR: It is found that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses.
Journal ArticleDOI
Effects of environmental enrichment on gene expression in the brain
Claire Rampon,Cecilia H. Jiang,Helin Dong,Helin Dong,Ya-Ping Tang,David J. Lockhart,Peter G. Schultz,Joe Z. Tsien,Yinghe Hu +8 more
TL;DR: expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission and may play important roles in modulating learning and memory capacity.
Journal ArticleDOI
Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.
TL;DR: In this review, the regulation of ubiquitination by enzymes of this pathway is discussed and some of the outstanding problems in understanding this regulation are highlighted.
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Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling
Ottavio V. Vitolo,Antonino Sant'Angelo,Vincenzo Costanzo,Fortunato Battaglia,Ottavio Arancio,Michael L. Shelanski +5 more
TL;DR: It is demonstrated that amyloid β-peptide treatment of cultured hippocampal neurons leads to the inactivation of protein kinase A (PKA) and persistence of its regulatory subunit PKAIIα, suggesting that Αβ acts directly on the pathways involved in the formation of late LTP and agents that enhance the cAMP/PKA/CREB-signaling pathway have potential for the treatment of AD.
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The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
Kenneth L. Rock,Colette F. Gramm,Lisa Rothstein,Karen Clark,Ross L. Stein,Lawrence Dick,Daniel Hwang,Alfred L. Goldberg +7 more
TL;DR: Peptide aldehydes that inhibit major peptidase activities of the 20S and 26S proteasomes are shown to reduce the degradation of protein and ubiquitinated protein substrates by 26S particles.
Book
Memory and Brain
TL;DR: Definitions: from synapses to behaviour Memory as synaptic change Memory and the developing nervous system Modulation of memory Localised and distributed memory storage The Penfield studies.
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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
Journal ArticleDOI
Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin
Gabriel Fenteany,Robert F. Standaert,William S. Lane,Soongyu Choi,E. J. Corey,Stuart L. Schreiber +5 more
TL;DR: Lactacystin appears to modify covalently the highly conserved amino-terminal threonine of the mammalian proteasome subunit X (also called MB1), a close homolog of the LMP7 proteasom subunit encoded by the major histocompatibility complex and may have a catalytic role.