Françoise Beslot

TL;DR: Observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.

TL;DR: Behavioural and biochemical results demonstrate the existence of a direct link between endogenous opioid and cannabinoid systems, however, chronic use of high doses of cannabinoids does not seem to potentiate the psychic dependence to opioids.

TL;DR: The results indicate that CB1 receptors are not involved in the antinociceptive responses to exogenous opioids, but that a physiological interaction between the opioid and cannabinoid systems is necessary to allow the development of opioid‐mediated responses to stress.

TL;DR: In conclusion, LAC ingestion induces anxiolytic-like and rewarding effects possibly related to serotonergic activation, and shifting transiently, the commonly consumed CAS-enriched to LAC-en enriched diets may induce beneficial effects on mood.

TL;DR: The results directly link the behavioural manifestations of cannabinoid withdrawal with the up‐regulation of the cyclic AMP pathway in the cerebellum, pointing towards common molecular adaptive mechanisms for dependence and withdrawal to most drugs of abuse; and suggest a particular role for the Cerebellum as a major neurobiological substrate for cannabinoid withdrawal.