C
Clara Dees
Researcher at University of Erlangen-Nuremberg
Publications - 91
Citations - 6052
Clara Dees is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Fibrosis & Transforming growth factor. The author has an hindex of 40, co-authored 88 publications receiving 5094 citations.
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Journal ArticleDOI
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Alfiya Akhmetshina,Katrin Palumbo,Clara Dees,Christina Bergmann,Paulius Venalis,Pawel Zerr,Angelika Horn,Trayana Kireva,Christian Beyer,Jochen Zwerina,Holm Schneider,Anika Sadowski,Marc Oliver Riener,Ormond A. MacDougald,Oliver Distler,Georg Schett,Jörg H W Distler +16 more
TL;DR: It is demonstrated that canonical Wnt signalling is necessary for TGF-β-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases.
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Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
Katrin Palumbo-Zerr,Pawel Zerr,Alfiya Distler,Judith Fliehr,Rossella Mancuso,Jingang Huang,Dirk Mielenz,Michal Tomcik,Barbara G. Fürnrohr,Carina Scholtysek,Clara Dees,Christian Beyer,Gerhard Krönke,Daniel Metzger,Oliver Distler,Georg Schett,Jörg H W Distler +16 more
TL;DR: The data demonstrate a regulatory role of NR4A1 in TGF-β signaling and fibrosis, providing the first proof of concept for targeting NR3A2 in fibrotic diseases and a potential target for anti-fibrotic therapies.
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Autophagy regulates TNFα-mediated joint destruction in experimental arthritis
Neng-Yu Lin,Christian Beyer,Andreas Giessl,Trayana Kireva,Carina Scholtysek,Stefan Uderhardt,Luis E. Muñoz,Clara Dees,Alfiya Distler,Stefan Wirtz,Gerhard Krönke,Brian Spencer,Oliver Distler,Georg Schett,Jörg H W Distler +14 more
TL;DR: It is demonstrated that autophagy is activated in RA in a TNFα-dependent manner and regulates osteoclast differentiation and bone resorption and provides evidence for a central role of autophagic pathways in joint destruction in RA.
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Platelet-derived serotonin links vascular disease and tissue fibrosis
Clara Dees,Alfiya Akhmetshina,Pawel Zerr,Nicole Reich,Katrin Palumbo,Angelika Horn,Astrid Jüngel,Christian Beyer,Gerhard Krönke,Jochen Zwerina,Rudolf Reiter,Natalia Alenina,Luc Maroteaux,Georg Schett,Oliver Distler,Jörg H W Distler +15 more
TL;DR: Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
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Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
Alfiya Akhmetshina,Paulius Venalis,Paulius Venalis,Clara Dees,Nicole Busch,Jochen Zwerina,Georg Schett,Oliver Distler,Jörg H W Distler +8 more
TL;DR: Results indicate that combined inhibition of the tyrosine kinase c-Abl and PDGF receptor might be effective in the later, less inflammatory stages of SSc and for the treatment of established fibrosis.