C
Christian Beyer
Researcher at University of Erlangen-Nuremberg
Publications - 100
Citations - 6183
Christian Beyer is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Fibrosis & Wnt signaling pathway. The author has an hindex of 41, co-authored 99 publications receiving 5318 citations.
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Journal ArticleDOI
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Alfiya Akhmetshina,Katrin Palumbo,Clara Dees,Christina Bergmann,Paulius Venalis,Pawel Zerr,Angelika Horn,Trayana Kireva,Christian Beyer,Jochen Zwerina,Holm Schneider,Anika Sadowski,Marc Oliver Riener,Ormond A. MacDougald,Oliver Distler,Georg Schett,Jörg H W Distler +16 more
TL;DR: It is demonstrated that canonical Wnt signalling is necessary for TGF-β-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases.
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The role of microparticles in the pathogenesis of rheumatic diseases.
TL;DR: As MPs appear in the blood in increased numbers during rheumatic disease, they represent novel biomarkers that can be used to assess events in otherwise inaccessible tissues and will define further the pathogenetic role of MPs and explore therapeutic strategies to block their release or signaling properties.
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Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
Katrin Palumbo-Zerr,Pawel Zerr,Alfiya Distler,Judith Fliehr,Rossella Mancuso,Jingang Huang,Dirk Mielenz,Michal Tomcik,Barbara G. Fürnrohr,Carina Scholtysek,Clara Dees,Christian Beyer,Gerhard Krönke,Daniel Metzger,Oliver Distler,Georg Schett,Jörg H W Distler +16 more
TL;DR: The data demonstrate a regulatory role of NR4A1 in TGF-β signaling and fibrosis, providing the first proof of concept for targeting NR3A2 in fibrotic diseases and a potential target for anti-fibrotic therapies.
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Autophagy regulates TNFα-mediated joint destruction in experimental arthritis
Neng-Yu Lin,Christian Beyer,Andreas Giessl,Trayana Kireva,Carina Scholtysek,Stefan Uderhardt,Luis E. Muñoz,Clara Dees,Alfiya Distler,Stefan Wirtz,Gerhard Krönke,Brian Spencer,Oliver Distler,Georg Schett,Jörg H W Distler +14 more
TL;DR: It is demonstrated that autophagy is activated in RA in a TNFα-dependent manner and regulates osteoclast differentiation and bone resorption and provides evidence for a central role of autophagic pathways in joint destruction in RA.
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Platelet-derived serotonin links vascular disease and tissue fibrosis
Clara Dees,Alfiya Akhmetshina,Pawel Zerr,Nicole Reich,Katrin Palumbo,Angelika Horn,Astrid Jüngel,Christian Beyer,Gerhard Krönke,Jochen Zwerina,Rudolf Reiter,Natalia Alenina,Luc Maroteaux,Georg Schett,Oliver Distler,Jörg H W Distler +15 more
TL;DR: Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.