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Attila Garami
Researcher at Max Planck Society
Publications - 6
Citations - 1318
Attila Garami is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mutant & Mannose. The author has an hindex of 5, co-authored 5 publications receiving 1251 citations. Previous affiliations of Attila Garami include Novartis & Friedrich Miescher Institute for Biomedical Research.
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Journal ArticleDOI
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
Attila Garami,Fried J. T. Zwartkruis,Takahiro Nobukuni,Manel Joaquin,Marta Roccio,Hugo Stocker,Sara C. Kozma,Ernst Hafen,Johannes L. Bos,George Thomas +9 more
TL;DR: Evidence is provided that TSC1/2 is a GAP for the small GTPase Rheb and that insulin-mediated RheB activation is PI3K dependent and that Rhe b overexpression induces S6K1 phosphorylation and inhibits PKBosphorylation, as do loss-of-function mutations in TSC 1/2.
Journal ArticleDOI
Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability
Attila Garami,Thomas Ilg +1 more
TL;DR: It is demonstrated that GDP‐mannose biosynthesis is not essential for Leishmania viability in culture, but constitutes a virulence pathway in these human pathogens.
Journal ArticleDOI
Glycosylation Defects and Virulence Phenotypes of Leishmania mexicana Phosphomannomutase and Dolicholphosphate-Mannose Synthase Gene Deletion Mutants
TL;DR: Man activation leading to GDP-Man as a virulence pathway in Leishmania is defined as a result against expectation and in contrast to the lethal phenotype observed in gene deletion experiments with fungi.
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The Role of Phosphomannose Isomerase in Leishmania mexicana Glycoconjugate Synthesis and Virulence
Attila Garami,Thomas Ilg +1 more
TL;DR: The cloned PMI gene from Leishmania mexicana provides the first conditional mannose-controlled system for parasite glycoconjugate assembly with potential applications for the investigation of their biosynthesis, intracellular sorting, and function.
Journal ArticleDOI
Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase.
James D. Stewart,Joan M Curtis,Timothy P. Spurck,Thomas Ilg,Attila Garami,Tracey M. Baldwin,Nathalie Courret,Geoffrey I. McFadden,Antony J. Davis,Emanuela Handman +9 more
TL;DR: Surprisingly, in view of the lack of several known host-protective antigens, injection of the mutant parasites into BALB/c mice confers significant and long lasting protection against infection, suggesting that these temperature sensitive mutants are an attractive candidate for a live attenuated vaccine.