Audrey Desgrange

TL;DR: Function and molecular aspects of nephron segmentation are reviewed with a particular interest on the signaling molecules and transcription factors recently implicated in kidney development in these three different vertebrate model organisms.

TL;DR: It is proposed that heart looping is not only a question of direction, but also one of fine-tuning shape, which is discussed in the context of evolutionary and clinical perspectives.

TL;DR: W Whole-exome or targeted exome sequencing of 183 unrelated familial and/or severe CAKUT-affected case subjects led to the identification of 16 heterozygous variants in GREB1L (growth regulation by estrogen in breast cancer 1-like), a gene reported as a target of retinoic acid signaling, which demonstrates that Greb1l plays a major role in early metanephros and genital development in mice and humans.

TL;DR: This work quantified shape changes during mouse heart looping, from 3D reconstructions by HREM, and identified sequential left-right asymmetries at the poles, which bias the buckling in opposite directions, thus leading to a helical shape.

TL;DR: High-resolution analyses during ureteric bud branching reveal that HNFB1 is required for maintaining cell-cell contacts, for proper epithelial cell organization and for further differentiation of the collecting duct system in mouse.