F
Francesca Tonelli
Researcher at University of Dundee
Publications - 36
Citations - 2953
Francesca Tonelli is an academic researcher from University of Dundee. The author has contributed to research in topics: Rab & Phosphorylation. The author has an hindex of 16, co-authored 33 publications receiving 2137 citations. Previous affiliations of Francesca Tonelli include Medical Research Council & Strathclyde Institute of Pharmacy and Biomedical Sciences.
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Journal ArticleDOI
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Martin Steger,Francesca Tonelli,Genta Ito,Paul Davies,Matthias Trost,Melanie Vetter,Stefanie Wachter,Esben Lorentzen,Graham Duddy,Stephen S. Wilson,Marco A. S. Baptista,Brian K. Fiske,Matthew J. Fell,John A. Morrow,Alastair D. Reith,Dario R. Alessi,Matthias Mann +16 more
TL;DR: This work employs a combination of phosphoproteomics, genetics, and pharmacology to unambiguously identify a subset of Rab GTPases as key LRRK2 substrates and a novel regulatory mechanism of Rabs that connects them to PD.
Journal ArticleDOI
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Martin Steger,Federico Diez,Herschel S. Dhekne,Pawel Lis,Raja Sekhar Nirujogi,Ozge Karayel,Francesca Tonelli,Terina N. Martinez,Esben Lorentzen,Suzanne R. Pfeffer,Dario R. Alessi,Matthias Mann +11 more
TL;DR: The results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may contribute to L RRK2-dependent pathologies.
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Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase
Elena Purlyte,Herschel S. Dhekne,Adil R. Sarhan,Rachel C Gomez,Pawel Lis,Melanie Wightman,Terina N. Martinez,Francesca Tonelli,Suzanne R. Pfeffer,Dario R. Alessi +9 more
TL;DR: The data reveal that Rab29 is a master regulator of LRRK2, controlling its activation, localization, and potentially biomarker phosphorylation of a cluster of highly studied biomarkerosphorylation sites.
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FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
Francesca Tonelli,Keng Gat Lim,Carolyn Loveridge,Jaclyn S. Long,Stuart M. Pitson,Stuart M. Pitson,Gabor Tigyi,Robert Bittman,Susan Pyne,Nigel J. Pyne +9 more
TL;DR: It is demonstrated that FTY720 (Fingolimod™) and (S)-FTY720 vinylphosphonate are novel inhibitors of SK1 catalytic activity and induce the proteasomal degradation of this enzyme in human pulmonary artery smooth muscle cells, MCF-7 breast cancer cells and androgen-independent LNCaP-AI prostate cancer cells.
Journal ArticleDOI
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Herschel S. Dhekne,Izumi Yanatori,Rachel C Gomez,Francesca Tonelli,Federico Diez,Birgitt Schüle,Martin Steger,Dario R. Alessi,Suzanne R. Pfeffer +8 more
TL;DR: It is shown that L RRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of LRRk2 R1441C mice, revealing a molecular pathway for regulating cilia function that likely contributes to Parkinson’s disease-specific pathology.