B. de Kruijff

TL;DR: In order to obtain more insight in the initial steps of the process of protein translocation across membranes, biophysical investigations were undertaken on the lipid specificity and structural consequences of penetration of the PhoE signal peptide into lipid model membranes and on the conformation of the signal peptides adopted upon interaction with the lipids.

TL;DR: The transbilayer distribution of palmitoyl lysophosphatidylcholine in these vesicles is such that they have a significantly higher content of the lyso-compound in the inner monolayer when compared with vesicle without glycophorin.

TL;DR: It is proposed that endogenous RNA present in mitochondria and mitoplasts is not accessible for adriamycin at low concentrations of the drug due to the presence of an intact lipid barrier, and the evidence for the potential importance of RNA as a target comes from experiments on outer membranes and microsomes.

TL;DR: 31P-NMR shows that poly(L-lysine) binding to cardiolipin, phosphatidylserine or phosph atidylglycerol does not affect the macroscopic structure or local order (in the phosphate region) of the phospholipids.

TL;DR: In these fused structures freeze-fracture electron microscopy reveals the appearance of particles, which is accompanied by the induction of an isotropic component in 31P NMR, and the localization of the cardiotoxin molecule in these structures is discussed.