B
B. de Kruijff
Researcher at Utrecht University
Publications - 204
Citations - 17134
B. de Kruijff is an academic researcher from Utrecht University. The author has contributed to research in topics: Bilayer & Vesicle. The author has an hindex of 71, co-authored 204 publications receiving 16788 citations. Previous affiliations of B. de Kruijff include ETH Zurich & Laboratory of Molecular Biology.
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Journal ArticleDOI
Effects of lysophosphatidylcholines on phosphatidylcholine and phosphatidylcholine/cholesterol liposome systems as revealed by 31P-NMR, electron microscopy and permeability studies
TL;DR: 31P-NMR demonstrates with increasing lysophosphatidylcholine concentrations in the bilayers of phosphatidycholines a decrease in the effective chemical shift anisotropy and a loss of K+-permeability barrier.
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Divalent cations and chlorpromazine can induce non-bilayer structures in phosphatidic acid-containing model membranes.
TL;DR: The structural organization of aqueous dispersions of 1,2-dioleoylphosphatidic acid has been investigated by freeze-fracture electron microscopy in relation to variations in pH, divalent cations and the local anaesthetic chlorpromazine.
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Effect of amphotericin B on cholesterol-containing liposomes of egg phosphatidylcholine and didocosenoyl phosphatidylcholine. A refinement of the model for the formation of pores by amphotericin B in membranes
P. Van Hoogevest,B. de Kruijff +1 more
TL;DR: A model is proposed which accounts for the effect of bilayer thickness on the amphotericin B-induced permeability changes in membranes.
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The role of charge and hydrophobicity in peptide-lipid interaction: a comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers.
TL;DR: The results allow a comparative analysis of the factors determining the extents and modes of lipid-model peptide interaction; in addition, the validity of the methods applied is discussed.
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Effects of cholesterol on the properties of equimolar mixtures of synthetic phosphatidylethanolamine and phosphatidylcholine. A 31P NMR and differential scanning calorimetry study.
TL;DR: The 31P NMR results indicate that when both species are in the liquid crystalline state the preferential interaction of cholesterol with the phosphatidylcholine component is maintained, and the effects do not therefore arise due to a preference of cholesterol for phospholipids in bilayer or non-bilayer phases.