Barbara A. Cornblatt

TL;DR: Analysis of data from the second North American Prodrome Longitudinal Study (NAPLS-2) provides the most precise estimate of prodrome duration to date, although results are limited to prodromes identified by ascertainment as being at CHR-P.

TL;DR: This issue commemorates the seminal contributions of Eugene Bleuler and is confronted with a climate in which the lay press finds occasion to call into question the very real progress that has been made in the understanding and treatment of mental illnesses.

TL;DR: This report summarizes the five major topics discussed throughout the workshop: (1) vulnerability and risk factors, (2) developmental issues, (3) neuroimaging and cognition, (4) alternative prevention strategies, and (5) clinical trials.

TL;DR: In this paper, the authors track the evolution of white matter abnormalities in a large, longitudinal cohort of clinical high risk individuals comprising the North American Prodrome Longitudinal Study (NAPLS-3) and fit linear mixed effects models to infer the impact of age and illness onset on variation in the fractional anisotropy of cellular tissue and the volume fraction of extracellular free water (FW).

TL;DR: Baseline negative symptoms and thought disorder appear to predict functional outcome for up to two years among adolescents and young adults at risk for psychosis and developing effective interventions to target these symptoms may be critical to promote functional recovery.