Showing papers in "Reproductive Toxicology in 2012"

TL;DR: It is concluded that zebrafish larvae can indeed be regarded as independently feeding from 120 h after fertilization, and should thus be subject to regulations for animal experiments from 120H after fertilized onwards.

TL;DR: Electronic cigarettes (EC) and refill fluids are distributed with little information on their pre- and postnatal health effects, and cytotoxicity was correlated with the number and concentration of chemicals used to flavor fluids.

TL;DR: The zebrafish embryo screen, by providing an integrated model of the developing vertebrate, compliments the ToxCast assay portfolio and has the potential to provide information relative to overt and organismal toxicity.

TL;DR: Analysis of the F3 generation sperm epigenome identified differential DNA methylation regions that can potentially be utilized as epigenetic biomarkers for transgenerational exposure and disease.

TL;DR: Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.

TL;DR: It is demonstrated that the zebrafish embryo/larva assay, may be used as screening tool for prioritization of compounds and could contribute to reduction of animal experiments in the field of developmental toxicology.

TL;DR: A series of studies was undertaken to establish pharmacokinetic parameters for PFOS in rats, mice, and monkeys after single oral and/or IV administration of K(+)PFOS, and rats and mice appeared to be more effective at eliminating PFOS than monkeys.

TL;DR: The current review paper summarizes the available evidence incriminating ROS and oxidative stress as the underlying pathophysiological mechanism leading to the onset of reproductive toxicity in each of these settings.

TL;DR: The two studies together found increasing activity of PPARα with increasing chain length of the PFAA up to perfluorononanoic acid (C9) and lower activity with longer chain PFAAs with both mouse and human PPAR α.

TL;DR: Prenatal exposure to informal e-waste recycling related to high rate of adverse birth outcomes, lower Apgar scores and unsafe lead level in cord blood in Guiyu and a control area in Xiamen.

TL;DR: ZEN reduced the quantity of healthy follicles, which may lead to premature oocyte depletion in adulthood, and was investigated in the F1-generation of pigs.

TL;DR: Associations of prenatal As and Cd exposures with multiple fetal size parameters measured by ultrasound in gestational week 14 and 30 in a population-based mother-child cohort in rural Bangladesh appeared to influence fetal development in a sex-dependent manner.

TL;DR: There was no indication that PFOA or PFOS was significantly associated with volume, sperm concentration, percent motility, swim-up motility and concentration, and directional motility (a function of motilityand modal progression).

TL;DR: Except at the 500,000 μg/kg/day dose, DEHP stimulated an increase in maternal and fetal serum testosterone and increased anogenital distance (AGD), and non-monotonic dose-response curves were noted for AGD and maternal, and testis testosterone.

TL;DR: The analysis of the ratios between the zebrafish embryo effect concentrations of both substances and human therapeutic plasma concentrations confirmed the teratogenic potential of warfarin, as well as the equivocal status of coumarin.

TL;DR: This report provides a progress update of a consortium effort to develop a harmonized zebrafish developmental toxicity assay by evaluating non-proprietary compounds exposed to embryos from pond-derived and cultivated strain wild types for lethality and morphological changes.

TL;DR: Protection of rutin and in particular quercetin on damages induced by lipid peroxidation was underlined and a possible role of these compounds in the supplementation of media used during semen handling warrants attention and further studies.

TL;DR: The close relationship between blood Cd levels and smoking habits indicates that Cd may be a relevant biomarker for smoking toxicity on fetal development and highlights the effect of Cd toxicity on prenatal growth through the probable accumulation and transmission of this metal through the placenta.

TL;DR: There is a need for modification of risk assessment procedures for pesticides, in order to take account of the mixture effects and cumulative intake, because of the potentially serious impact of mixed exposure on development and reproduction in humans.

TL;DR: Cumulative adverse effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, are indicated.

TL;DR: Late gestational exposure to MEHP leads to multiple latent reproductive effects throughout murine life resulting in premature ovarian senescence and mammary hyperplasia, both of which are observed in high dose MEHP-exposed females.

TL;DR: Free BPA comprised 83% and 91% of total BPA in second and third trimester amniotic fluid, respectively, when detected, increasing fetal exposure to free BPA.

TL;DR: The results of this systematic review suggest that IFN-α does not significantly increase the risk of major malformation, miscarriage, stillbirth or preterm delivery above general population rates and it is also possible that IFn-α may have a protective effect against pregnancy loss in cases of ET.

TL;DR: This review will address the rodent (rat) cancer data and cancer Mode of Action of PFOA for tumors of the liver, testes and pancreas for tumor induction in rats following chronic dietary administration.

TL;DR: In this article, the effects of perfluorooctanoic acid (PFOA) on PPAR-regulated genes were investigated in mice with pregnant CD-1 mice.

TL;DR: Different aromatase regulation profiles are observed between animals with similar estrogen-to-androgen ratios but with different chemical treatments, and measurement of many endpoints is necessary for good risk assessment.

TL;DR: Maternal undernutrition resulted in a significant decrease in P-gp protein expression in the placenta and fetal brain, but not the maternal brain, which indicates that maternal undernutrition may impact on fetal exposure to drugs administered to the mother during pregnancy due to changes in placental transfer.

TL;DR: The results indicate that oxidative stress and both intrinsic and extrinsic cell death pathways were involved in prenatal PFOS exposure-induced injuries in postnatal lungs.

TL;DR: Overall, this study demonstrates that triclosan may indirectly disrupt steroidogenesis which may, in turn, affect placental development and consequently fetal growth.

TL;DR: The long-lasting effects of perinatal exposure to low doses of xenoestrogens included delayed MG differentiation, altered milk yield and modified milk composition.