R
Ruth Volland
Researcher at University of Cologne
Publications - 24
Citations - 1637
Ruth Volland is an academic researcher from University of Cologne. The author has contributed to research in topics: Neuroblastoma & Transcriptome. The author has an hindex of 15, co-authored 24 publications receiving 1226 citations. Previous affiliations of Ruth Volland include Boston Children's Hospital.
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Journal ArticleDOI
Telomerase activation by genomic rearrangements in high-risk neuroblastoma
Martin Peifer,Falk Hertwig,Frederik Roels,Daniel Dreidax,Moritz Gartlgruber,Roopika Menon,Andrea Krämer,Justin L. Roncaioli,Frederik Sand,Johannes M. Heuckmann,Fakhera Ikram,Rene Schmidt,Sandra Ackermann,Anne Engesser,Yvonne Kahlert,Wenzel Vogel,Janine Altmüller,Peter Nürnberg,Jean Thierry-Mieg,Danielle Thierry-Mieg,Aruljothi Mariappan,Stefanie Heynck,Erika Mariotti,Kai-Oliver Henrich,Christian Gloeckner,Graziella Bosco,Ivo Leuschner,Michal R. Schweiger,Larissa Savelyeva,Simon C. Watkins,Chunxuan Shao,Emma Bell,Thomas Höfer,Viktor Achter,Ulrich Lang,Jessica Theissen,Ruth Volland,Maral Saadati,Angelika Eggert,Bram De Wilde,Frank Berthold,Zhiyu Peng,Chen Zhao,Leming Shi,Monika Ortmann,Reinhard Büttner,Sven Perner,Barbara Hero,Alexander Schramm,Johannes H. Schulte,Johannes H. Schulte,Carl Herrmann,Carl Herrmann,Roderick J. O’Sullivan,Frank Westermann,Roman K. Thomas,Matthias G. Fischer +56 more
TL;DR: It is shown that remodelling of the genomic context abrogates transcriptional silencing of TERT in high-risk neuroblastoma and places telomerase activation in the centre of transformation in a large fraction of these tumours.
Journal ArticleDOI
Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.
Wenqian Zhang,Ying Yu,Falk Hertwig,Falk Hertwig,Jean Thierry-Mieg,Wenwei Zhang,Danielle Thierry-Mieg,Jian Wang,Cesare Furlanello,Viswanath Devanarayan,Jie Cheng,Youping Deng,Barbara Hero,Huixiao Hong,Meiwen Jia,Li Li,Simon Lin,Yuri Nikolsky,André Oberthuer,Tao Qing,Zhenqiang Su,Ruth Volland,Charles Wang,May D. Wang,Junmei Ai,Davide Albanese,Shahab Asgharzadeh,Smadar Avigad,Wenjun Bao,Marina Bessarabova,Murray H. Brilliant,Benedikt Brors,Marco Chierici,Tzu-Ming Chu,Jibin Zhang,Richard Grundy,Min Max He,Scott J. Hebbring,Howard L. Kaufman,Samir Lababidi,Lee Lancashire,Yan Li,Xin X. Lu,Heng Luo,Heng Luo,Xiwen Ma,Baitang Ning,Rosa Noguera,Martin Peifer,John H. Phan,Frederik Roels,Frederik Roels,Carolina Rosswog,Susan Shao,Jie Shen,Jessica Theissen,Gian Paolo Tonini,Jo Vandesompele,Po-Yen Wu,Wenzhong Xiao,Joshua Xu,Weihong Xu,Jiekun Xuan,Yong Yang,Zhan Ye,Zirui Dong,Ke Zhang,Ye Yin,Chen Zhao,Yuanting Zheng,Russell D. Wolfinger,Tieliu Shi,Linda H. Malkas,Frank Berthold,Frank Berthold,Jun Wang,Weida Tong,Leming Shi,Leming Shi,Zhiyu Peng,Matthias Fischer,Matthias Fischer +81 more
TL;DR: It is demonstrated thatRNA-seq outperforms microarrays in determining the transcriptomic characteristics of cancer, while RNA-seq and microarray-based models perform similarly in clinical endpoint prediction.
Journal ArticleDOI
A mechanistic classification of clinical phenotypes in neuroblastoma
Sandra Ackermann,Sandra Ackermann,Maria Cartolano,Barbara Hero,Anne Welte,Anne Welte,Yvonne Kahlert,Yvonne Kahlert,Andrea Roderwieser,Andrea Roderwieser,Christoph Bartenhagen,Christoph Bartenhagen,Esther Walter,Esther Walter,Judith Gecht,Laura Kerschke,Ruth Volland,Roopika Menon,Johannes M. Heuckmann,Moritz Gartlgruber,Sabine Hartlieb,Kai-Oliver Henrich,Konstantin Okonechnikov,Janine Altmüller,Peter Nürnberg,Steve Lefever,Bram De Wilde,Frederik Sand,Frederik Sand,Fakhera Ikram,Fakhera Ikram,Fakhera Ikram,Carolina Rosswog,Carolina Rosswog,Janina Fischer,Janina Fischer,Jessica Theissen,Falk Hertwig,Aatur D. Singhi,Thorsten Simon,Wenzel Vogel,Sven Perner,Barbara Krug,Matthias Schmidt,Sven Rahmann,Sven Rahmann,Viktor Achter,Ulrich Lang,Christian Vokuhl,Monika Ortmann,Reinhard Büttner,Angelika Eggert,Franki Speleman,Roderick J. O’Sullivan,Roman K. Thomas,Frank Berthold,Jo Vandesompele,Alexander Schramm,Frank Westermann,Johannes H. Schulte,Martin Peifer,Matthias Fischer,Matthias Fischer +62 more
TL;DR: This work sequenced more than 400 pretreatment neuroblastomas and identified molecular features that characterize the three distinct clinical outcomes, and proposed a mechanistic classification of neuroblastoma that may benefit the clinical management of patients.
Journal ArticleDOI
Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
Tanmoy Mondal,Prasanna Kumar Juvvuna,Agnete Kirkeby,Agnete Kirkeby,Sanhita Mitra,Subazini Thankaswamy Kosalai,Larissa Traxler,Falk Hertwig,Falk Hertwig,Sara Wernig-Zorc,Caroline Miranda,Lily Deland,Ruth Volland,Christoph Bartenhagen,Deniz Bartsch,Sashidhar Bandaru,Anne Engesser,Santhilal Subhash,Tommy Martinsson,Helena Carén,Levent M. Akyürek,Leo Kurian,Meena Kanduri,Maite Huarte,Per Kogner,Matthias Fischer,Chandrasekhar Kanduri +26 more
TL;DR: 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene, and this regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies.
Journal ArticleDOI
Vitamin B6 in Primary Hyperoxaluria I: First Prospective Trial after 40 Years of Practice
Heike Hoyer-Kuhn,Sina Kohbrok,Ruth Volland,Jeremy Franklin,Barbara Hero,Bodo B. Beck,Bernd Hoppe +6 more
TL;DR: This first prospective trial confirmed B6 efficacy in 50% of patients (three of three homozygous, one of five heterozygous and two of four patients negative for the Gly170Arg and/or Phe152Ile mutations).