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Barbara Tomassini
Researcher at University of Rome Tor Vergata
Publications - 19
Citations - 1430
Barbara Tomassini is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Frataxin & Apoptosis. The author has an hindex of 14, co-authored 19 publications receiving 1367 citations. Previous affiliations of Barbara Tomassini include Sapienza University of Rome.
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Journal ArticleDOI
Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis
Ruggero De Maria,Luisa Lenti,Luisa Lenti,Florence Malisan,Florence Malisan,Federica D'Agostino,Federica D'Agostino,Barbara Tomassini,Barbara Tomassini,Ann Zeuner,Ann Zeuner,Maria Rita Rippo,Maria Rita Rippo,Roberto Testi,Roberto Testi +14 more
TL;DR: GD3 ganglioside mediates the propagation of CD95-generated apoptotic signals in hematopoietic cells and Pharmacological inhibition of GD3 synthesis and exposure to GD3 synthase antisense oligodeoxynucleotides preventedCD95-induced apoptosis.
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Caspases Mediate Retinoic Acid–Induced Degradation of the Acute Promyelocytic Leukemia PML/RARα Fusion Protein
Clara Nervi,Fabiana Fosca Ferrara,Mirco Fanelli,Maria Rita Rippo,Barbara Tomassini,Pier Francesco Ferrucci,Martin Ruthardt,Vania Gelmetti,Carlo Gambacorti-Passerini,Daniela Diverio,Francesco Grignani,Pier Giuseppe Pelicci,Roberto Testi +12 more
TL;DR: Results indicate that PML/RARalpha is directly involved in conferring RA sensitivity of APL cells and that the RA-induced reassembly of PML NBs is the consequence of the disappearance of PMl/Raralpha.
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GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion
Maria Rita Rippo,Florence Malisan,Luigi Ravagnan,Barbara Tomassini,Ivano Condò,P. Costantini,Santos A. Susin,Alessandra Rufini,Matilde Todaro,Guido Kroemer,Roberto Testi +10 more
TL;DR: It is shown that mitochondria are a key destination for apoptogenic GD3 ganglioside along the lipid pathway to programmed cell death and indicate that relevant GD3 targets are under bcl‐2 control.
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In vivo maturation of human frataxin
Ivano Condò,Natascia Ventura,Florence Malisan,Alessandra Rufini,Barbara Tomassini,Roberto Testi +5 more
TL;DR: The data indicate that frataxin(56-210) can be produced in vivo when the primary 80-81 maturation site is unavailable, suggesting the existence of proteolytic mechanisms that can actively control the size of the mature product, with possible functional implications.
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Acetylation Suppresses the Proapoptotic Activity of GD3 Ganglioside
Florence Malisan,Luigi Franchi,Barbara Tomassini,Natascia Ventura,Ivano Condò,Maria Rita Rippo,Alessandra Rufini,Laura Liberati,Claudia Nachtigall,Bernhard Kniep,Roberto Testi +10 more
TL;DR: Sialic acid acetylation critically controls the proapoptotic activity of GD3 and is sufficient to induce apoptosis of glioblastomas which express high levels of 9-O-acetyl-GD3.