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Barry P. Sleckman
Researcher at University of Alabama at Birmingham
Publications - 149
Citations - 11690
Barry P. Sleckman is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Gene & DNA repair. The author has an hindex of 51, co-authored 143 publications receiving 10697 citations. Previous affiliations of Barry P. Sleckman include University of Washington & Harvard University.
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Journal ArticleDOI
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Ken Cadwell,John Y. Liu,Sarah L. Brown,Hiroyuki Miyoshi,Joy Loh,Jochen K. Lennerz,Chieko Kishi,Wumesh Kc,Javier A. Carrero,Steven C. Hunt,Christian D. Stone,Elizabeth M. Brunt,Ramnik J. Xavier,Barry P. Sleckman,Ellen Li,Noboru Mizushima,Thaddeus S. Stappenbeck,Herbert W. Virgin +17 more
TL;DR: ATG16L1, and probably the process of autophagy, have a role within the intestinal epithelium of mice and Crohn’s disease patients by selective effects on the cell biology and specialized regulatory properties of Paneth cells.
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Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
Susanne J. Szabo,Brandon M. Sullivan,Claudia Stemmann,Abhay R. Satoskar,Barry P. Sleckman,Laurie H. Glimcher +5 more
TL;DR: The regulation of a single cytokine, IFN-γ, is controlled by distinct transcriptional mechanisms within the T cell lineage, which is vital for the control of microbial pathogens.
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ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.
Andrea L. Bredemeyer,Girdhar G. Sharma,Ching-Yu Huang,Beth A. Helmink,Laura M. Walker,Katrina C. Khor,Beth Nuskey,Kathleen E. Sullivan,Tej K. Pandita,Craig H. Bassing,Barry P. Sleckman +10 more
TL;DR: It is shown that ATM also functions directly in the repair of chromosomal DNA DSBs by maintaining DNA ends in repair complexes generated during lymphocyte antigen receptor gene assembly, providing a molecular explanation for the increase in lymphoid tumours with translocations involving antigen receptor loci associated with ataxia-telangiectasia.
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The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Dinis Pedro Calado,Yoshiteru Sasaki,Susana A. Godinho,Alex Pellerin,Karl Köchert,Barry P. Sleckman,Ignacio Moreno de Alboran,Martin Janz,Martin Janz,Scott J. Rodig,Klaus Rajewsky,Klaus Rajewsky +11 more
TL;DR: This article identified c-Myc(+) B cell subpopulations in immature and mature GCs and found that they had indispensable roles in the formation and maintenance of GCs by genetic ablation of Myc.
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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
Elsa Callen,Michela Di Virgilio,Michael J. Kruhlak,Maria Nieto-Soler,Nancy Wong,Hua Tang Chen,Robert B. Faryabi,Federica Polato,Margarida A. Santos,Linda M. Starnes,Duane R. Wesemann,Ji-Eun Lee,Anthony T. Tubbs,Barry P. Sleckman,Jeremy A. Daniel,Kai Ge,Frederick W. Alt,Oscar Fernandez-Capetillo,Michel C. Nussenzweig,André Nussenzweig +19 more
TL;DR: It is concluded that 53BP1 promotes productive CSR and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP.