T
Thaddeus S. Stappenbeck
Researcher at Washington University in St. Louis
Publications - 182
Citations - 25088
Thaddeus S. Stappenbeck is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Stem cell & Intestinal mucosa. The author has an hindex of 66, co-authored 166 publications receiving 20497 citations.
Papers
More filters
Journal ArticleDOI
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
Mahesh Desai,Mahesh Desai,Anna M. Seekatz,Nicole M. Koropatkin,Nobuhiko Kamada,Christina A. Hickey,Mathis Wolter,Nicholas A. Pudlo,Sho Kitamoto,Nicolas Terrapon,Arnaud Muller,Vincent B. Young,Bernard Henrissat,Paul Wilmes,Thaddeus S. Stappenbeck,Gabriel Núñez,Eric C. Martens +16 more
TL;DR: Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium.
Journal ArticleDOI
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Ken Cadwell,John Y. Liu,Sarah L. Brown,Hiroyuki Miyoshi,Joy Loh,Jochen K. Lennerz,Chieko Kishi,Wumesh Kc,Javier A. Carrero,Steven C. Hunt,Christian D. Stone,Elizabeth M. Brunt,Ramnik J. Xavier,Barry P. Sleckman,Ellen Li,Noboru Mizushima,Thaddeus S. Stappenbeck,Herbert W. Virgin +17 more
TL;DR: ATG16L1, and probably the process of autophagy, have a role within the intestinal epithelium of mice and Crohn’s disease patients by selective effects on the cell biology and specialized regulatory properties of Paneth cells.
Journal ArticleDOI
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.
Jason Lloyd-Price,Jason Lloyd-Price,Cesar Arze,Ashwin N. Ananthakrishnan,Melanie Schirmer,Melanie Schirmer,Julian Avila-Pacheco,Tiffany W. Poon,Elizabeth Andrews,Nadim J. Ajami,Kevin S. Bonham,Kevin S. Bonham,Colin J. Brislawn,David Casero,Holly Courtney,Antonio Gonzalez,Thomas G. Graeber,A. Brantley Hall,Kathleen Lake,Carol J. Landers,Himel Mallick,Himel Mallick,Damian R. Plichta,Mahadev Prasad,Gholamali Rahnavard,Gholamali Rahnavard,Jenny S. Sauk,Dmitry Shungin,Dmitry Shungin,Yoshiki Vázquez-Baeza,Richard A. White,Jonathan Braun,Lee A. Denson,Lee A. Denson,Janet K. Jansson,Rob Knight,Subra Kugathasan,Dermot P.B. McGovern,Joseph F. Petrosino,Thaddeus S. Stappenbeck,Harland S. Winter,Clary B. Clish,Eric A. Franzosa,Hera Vlamakis,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier,Curtis Huttenhower,Curtis Huttenhower +48 more
TL;DR: It is demonstrated that periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts, and integrative analysis identified microbial, biochemical, and host factors central to this dysregulation.
Journal ArticleDOI
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells.
TL;DR: Findings reveal a previously unappreciated mechanism of postnatal animal development, where microbes colonizing a mucosal surface are assigned responsibility for regulating elaboration of the underlying microvasculature by signaling through a bacteria-sensing epithelial cell.
Journal ArticleDOI
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Jason M. Norman,Scott A. Handley,Megan T. Baldridge,Lindsay Droit,Catherine Y. Liu,Brian C. Keller,Amal Kambal,Cynthia L. Monaco,Guoyan Zhao,Phillip Fleshner,Thaddeus S. Stappenbeck,Dermot P.B. McGovern,Ali Keshavarzian,Ece Mutlu,Jenny Sauk,Dirk Gevers,Ramnik J. Xavier,Ramnik J. Xavier,David Wang,Miles Parkes,Herbert W. Virgin +20 more
TL;DR: It is concluded that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.