H
Hua Tang Chen
Researcher at National Institutes of Health
Publications - 25
Citations - 8933
Hua Tang Chen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 24, co-authored 25 publications receiving 8326 citations. Previous affiliations of Hua Tang Chen include University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Samuel F. Bunting,Elsa Callen,Nancy Wong,Hua Tang Chen,Federica Polato,Amanda Gunn,Anne Bothmer,Niklas Feldhahn,Oscar Fernandez-Capetillo,Liu Cao,Xiaoling Xu,Chu-Xia Deng,Toren Finkel,Michel C. Nussenzweig,Michel C. Nussenzweig,Jeremy M. Stark,André Nussenzweig +16 more
TL;DR: It is shown that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA ligase 4, illustrating that HR and NHEJ compete to process DNA breaks that arise during DNA replication.
Journal ArticleDOI
Genomic instability in mice lacking histone H2AX.
Arkady Celeste,Simone Petersen,Peter J. Romanienko,Oscar Fernandez-Capetillo,Hua Tang Chen,Olga A. Sedelnikova,Bernardo Reina-San-Martin,Vincenzo Coppola,Eric Meffre,Michael J. Difilippantonio,Christophe E. Redon,Duane R. Pilch,Alexandru Olaru,Michael Eckhaus,R. Daniel Camerini-Otero,Lino Tessarollo,Ferenc Livak,Katia Manova,William M. Bonner,Michel C. Nussenzweig,André Nussenzweig +20 more
TL;DR: Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage, and H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA.
Journal ArticleDOI
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Oscar Fernandez-Capetillo,Hua Tang Chen,Arkady Celeste,Irene M. Ward,Peter J. Romanienko,Julio C. Morales,Kazuhito Naka,Zhengfang Xia,R. Daniel Camerini-Otero,Noboru Motoyama,Phillip B. Carpenter,William M. Bonner,Junjie Chen,André Nussenzweig +13 more
TL;DR: It is proposed that at threshold levels of DNA damage, H2AX-mediated concentration of 53BP1 at double-strand breaks is essential for the amplification of signals that might otherwise be insufficient to prevent entry of damaged cells into mitosis.
Journal ArticleDOI
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
Michael J. Difilippantonio,Jie Zhu,Hua Tang Chen,Eric Meffre,Michel C. Nussenzweig,Edward E. Max,Thomas Ried,André Nussenzweig +7 more
TL;DR: Ku80 is a caretaker gene that maintains the integrity of the genome by a mechanism involving the suppression of chromosomal rearrangements, reminiscent of Burkitt's lymphoma.
Journal ArticleDOI
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
Simone Petersen,Rafael Casellas,Bernardo Reina-San-Martin,Hua Tang Chen,Michael J. Difilippantonio,Patrick C. Wilson,Leif Hanitsch,Arkady Celeste,Masamichi Muramatsu,Duane R. Pilch,Christophe E. Redon,Thomas Ried,William M. Bonner,Tasuku Honjo,Michel C. Nussenzweig,André Nussenzweig +15 more
TL;DR: It is reported that the Nijmegen breakage syndrome protein and phosphorylated H2A histone family member X (γ-H2AX) form nuclear foci at the Ch region in the G1 phase of the cell cycle in cells undergoing CSR, and that switching is impaired in H2AX-/- mice.