B
Beatrix Fauler
Researcher at Max Planck Society
Publications - 23
Citations - 8748
Beatrix Fauler is an academic researcher from Max Planck Society. The author has contributed to research in topics: Induced pluripotent stem cell & Biology. The author has an hindex of 9, co-authored 20 publications receiving 7172 citations.
Papers
More filters
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Journal ArticleDOI
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.
TL;DR: It is demonstrated that somatic mitochondria within human iPSCs revert to an immature ESC‐like state with respect to organelle morphology and distribution, expression of nuclear factors involved in mitochondrial biogenesis, content of mitochondrial DNA, intracellular ATP level, oxidative damage, and lactate generation, and suggest that cellular reprogramming can modulate the mitochondrial/oxidative stress pathway, thus inducing a rejuvenated state capable of escaping cellular senescence.
Journal ArticleDOI
Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
Carmen Lorenz,Pierre Lesimple,Pierre Lesimple,Pierre Lesimple,Raul Bukowiecki,Annika Zink,Annika Zink,Gizem Inak,Barbara Mlody,Manvendra K. Singh,Marcus Semtner,Nancy Mah,Karine Auré,Karine Auré,Karine Auré,Megan Leong,Oleksandr Zabiegalov,Ekaterini-Maria Lyras,Vanessa Pfiffer,Beatrix Fauler,Jenny Eichhorst,Burkhard Wiesner,Norbert Huebner,Josef Priller,Thorsten Mielke,David Meierhofer,Zsuzsanna Izsvák,Jochen C. Meier,Frédéric Bouillaud,Frédéric Bouillaud,Frédéric Bouillaud,James Adjaye,Markus Schuelke,Erich E. Wanker,Anne Lombès,Anne Lombès,Anne Lombès,Alessandro Prigione +37 more
TL;DR: It is shown that neural progenitor cells derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic switch toward oxidative phosphorylation, and that iPSC-derived NPCs provide an effective model for drug screening to target mtDNA disorders that affect the nervous system.
Journal ArticleDOI
Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
Alessandro Prigione,Amir M. Hossini,Björn Lichtner,Akdes Serin,Beatrix Fauler,Matthias Megges,Rudi Lurz,Hans Lehrach,E. Makrantonaki,Christos C. Zouboulis,James Adjaye +10 more
TL;DR: It will be essential to develop reprogramming protocols capable of safeguarding the integrity of the genome of aged somatic cells, before employing iPSC-based therapies for age-associated disorders, according to concerns over the oncogenic potential of reprogrammed cells.
Journal ArticleDOI
FGF Inhibition Directs BMP4-Mediated Differentiation of Human Embryonic Stem Cells to Syncytiotrophoblast
TL;DR: It is shown that FGF inhibition alone, or in combination with either ACTIVIN/NODAL inhibition or BMP activation, supports hESC differentiation to hCG-secreting syncytiotrophoblast, and that the inhibition of the FGF pathway acts as a key in directing BMP4-mediated hESCs differentiation to syn Cytiotrophicoblast.