Beatrix Fauler

TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.

TL;DR: It is demonstrated that somatic mitochondria within human iPSCs revert to an immature ESC‐like state with respect to organelle morphology and distribution, expression of nuclear factors involved in mitochondrial biogenesis, content of mitochondrial DNA, intracellular ATP level, oxidative damage, and lactate generation, and suggest that cellular reprogramming can modulate the mitochondrial/oxidative stress pathway, thus inducing a rejuvenated state capable of escaping cellular senescence.

TL;DR: It is shown that neural progenitor cells derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic switch toward oxidative phosphorylation, and that iPSC-derived NPCs provide an effective model for drug screening to target mtDNA disorders that affect the nervous system.

TL;DR: It will be essential to develop reprogramming protocols capable of safeguarding the integrity of the genome of aged somatic cells, before employing iPSC-based therapies for age-associated disorders, according to concerns over the oncogenic potential of reprogrammed cells.

TL;DR: It is shown that FGF inhibition alone, or in combination with either ACTIVIN/NODAL inhibition or BMP activation, supports hESC differentiation to hCG-secreting syncytiotrophoblast, and that the inhibition of the FGF pathway acts as a key in directing BMP4-mediated hESCs differentiation to syn Cytiotrophicoblast.