Beatriz Perez-Villamil

TL;DR: An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.

TL;DR: It is shown that MV130 promotes the generation of Th1/Th17 responses via receptor‐interacting serine/threonine‐protein kinase‐2 (RIPK2)‐ and myeloid‐differentiation primary‐response gene‐88 (MyD88)‐mediated signalling pathways under the control of IL‐10, and elucidate immunological mechanisms underlying the potential way of action of MV130.

TL;DR: It is shown that specific SOD3 re-expression in tumor-associated endothelial cells (ECs) increases doxorubicin delivery into and chemotherapeutic effect on tumors, via the HIF-2a/VE-cadherin pathway.

TL;DR: Favorable prognosis in completely resected NSCLC is determined by a B-cell-mediated immune response that can be differently scored by a 50-gene expression profile or by CD20 immunostaining, and may become a new tool for determining individualized adjuvant therapies.

TL;DR: The findings suggest that SOD3-induced upregulation of LAMA4 in endothelial cells boosts selective tumor infiltration by T lymphocytes, thus transforming immunologically “cold” into “hot” tumors.