T
Ted Laderas
Researcher at Oregon Health & Science University
Publications - 22
Citations - 3762
Ted Laderas is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Myeloid leukemia & Metastability. The author has an hindex of 11, co-authored 21 publications receiving 2721 citations. Previous affiliations of Ted Laderas include Translational Research Institute & Sage Bionetworks.
Papers
More filters
Journal ArticleDOI
The consensus molecular subtypes of colorectal cancer
Justin Guinney,Rodrigo Dienstmann,Rodrigo Dienstmann,Xingwu Wang,Xingwu Wang,Aurélien de Reyniès,Andreas Schlicker,Charlotte Soneson,Laetitia Marisa,Paul Roepman,Gift Nyamundanda,Paolo Angelino,Brian M. Bot,Jeffrey S. Morris,Iris Simon,Sarah Gerster,Evelyn Fessler,Felipe De Sousa E Melo,Edoardo Missiaglia,Hena R. Ramay,David Barras,Krisztian Homicsko,Dipen M. Maru,Ganiraju C. Manyam,Bradley M. Broom,Valérie Boige,Beatriz Perez-Villamil,Ted Laderas,Ramon Salazar,Joe W. Gray,Douglas Hanahan,Josep Tabernero,René Bernards,Stephen H. Friend,Pierre Laurent-Puig,Jan Paul Medema,Anguraj Sadanandam,Lodewyk F. A. Wessels,Mauro Delorenzi,Mauro Delorenzi,Scott Kopetz,Louis Vermeulen,Sabine Tejpar +42 more
TL;DR: An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.
Journal ArticleDOI
CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.
David K. Edwards,Kevin Watanabe-Smith,Angela Rofelty,Alisa Damnernsawad,Ted Laderas,Adam J. Lamble,Evan F. Lind,Andy Kaempf,Motomi Mori,Mara Rosenberg,Amanda d’Almeida,Nicola Long,Anupriya Agarwal,David Sweeney,Marc M. Loriaux,Shannon K. McWeeney,Jeffrey W. Tyner +16 more
TL;DR: The results suggest that CSF1R-expressing cells support the bulk leukemia population through the secretion of HGF and other cytokines, including hepatocyte growth factor (HGF).
Journal ArticleDOI
Metastability of a Supercompressed Fluid Monolayer
TL;DR: Observations indicate that in several respects, the supercompression of POPC monolayers resembles the supercooling of three-dimensional liquids toward a glass transition.
Journal ArticleDOI
Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia.
Adam J. Lamble,Yoko Kosaka,Ted Laderas,Allie Maffit,Andy Kaempf,Lauren K. Brady,Weiwei Wang,Nicola Long,Jennifer N. Saultz,Motomi Mori,David Soong,Clare Lefave,Fei Huang,Homer Adams,Marc M. Loriaux,Cristina E. Tognon,Pierrette Lo,Jeffrey W. Tyner,Guang Fan,Shannon K. McWeeney,Brian J. Druker,Brian J. Druker,Evan F. Lind +22 more
TL;DR: The data demonstrate that AML establishes an immune suppressive environment in the bone marrow, in part through T cell checkpoint function, which supports the development of immune checkpoint therapy to combat this deadly disease.
Journal ArticleDOI
The melting of pulmonary surfactant monolayers
TL;DR: The distinct melting points for TC DPPC and supercompressed CLSE provide the basis by which the nature of the alveolar film might be determined from the temperature-dependence of pulmonary mechanics.