B
Bekim Sadikovic
Researcher at London Health Sciences Centre
Publications - 161
Citations - 4009
Bekim Sadikovic is an academic researcher from London Health Sciences Centre. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 30, co-authored 112 publications receiving 2807 citations. Previous affiliations of Bekim Sadikovic include McMaster University Medical Centre & University Health Network.
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Journal ArticleDOI
Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma
Nilva K. Cervigne,Patricia P Reis,Jerry Machado,Bekim Sadikovic,Grace Bradley,Natalie Naranjo Galloni,Melania Pintilie,Igor Jurisica,Bayardo Perez-Ordonez,Ralph W. Gilbert,Patrick J. Gullane,Jonathan C. Irish,Suzanne Kamel-Reid,Suzanne Kamel-Reid +13 more
TL;DR: This study provides the first evidence of an miR signature potentially useful for identifying leukoplakias at risk of malignant transformation, and its findings were validated using quantitative RT-PCR in an independent cohort of 52 progressive dysplasias and OSCCs, and five non-progressive dysplAsias.
Journal ArticleDOI
Cause and consequences of genetic and epigenetic alterations in human cancer.
TL;DR: A model of tumourigenesis is provided that addresses the combined impact of both epigenetic and genetic alterations in cancer cells and considers the associated interactions of genetic and epigenetic processes in tumour onset and progression.
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The clinical application of genome-wide sequencing for monogenic diseases in Canada: Position Statement of the Canadian College of Medical Geneticists
Kym M. Boycott,Taila Hartley,Shelin Adam,Francois P. Bernier,Karen Chong,Karen Chong,Bridget A. Fernandez,Jan M. Friedman,Michael T. Geraghty,Stacey Hume,Bartha Maria Knoppers,Anne-Marie Laberge,Jacek Majewski,Roberto Mendoza-Londono,M. Stephen Meyn,M. Stephen Meyn,Jacques L. Michaud,Tanya N. Nelson,Julie Richer,Bekim Sadikovic,David Skidmore,Tracy Stockley,Sherry Taylor,Clara D.M. van Karnebeek,Ma'n H. Zawati,Julie Lauzon,Christine M. Armour +26 more
TL;DR: Clinical genome-wide sequencing is an appropriate approach in the diagnostic assessment of a patient for whom there is suspicion of a significant monogenic disease that is associated with a high degree of genetic heterogeneity, or where specific genetic tests have failed to provide a diagnosis.
Journal ArticleDOI
Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders
Erfan Aref-Eshghi,Jennifer Kerkhof,Victor P. Pedro,Mouna Barat-Houari,Nathalie Ruiz-Pallares,Jean-Christophe Andrau,Didier Lacombe,Julien Van-Gils,Patricia Fergelot,Christèle Dubourg,Valérie Cormier-Daire,Sophie Rondeau,François Lecoquierre,Pascale Saugier-Veber,Gaël Nicolas,Gaetan Lesca,Nicolas Chatron,Damien Sanlaville,Antonio Vitobello,Laurence Faivre,Christel Thauvin-Robinet,Frédéric Laumonnier,Martine Raynaud,Marielle Alders,Marcel M.A.M. Mannens,Peter Henneman,Raoul C.M. Hennekam,Guillaume Velasco,Claire Francastel,Damien Ulveling,Andrea Ciolfi,Simone Pizzi,Marco Tartaglia,Solveig Heide,Delphine Héron,Cyril Mignot,Boris Keren,Sandra Whalen,Alexandra Afenjar,Thierry Bienvenu,Philippe M. Campeau,Justine Rousseau,Michael A. Levy,Lauren Brick,Mariya Kozenko,Tugce B. Balci,Victoria Mok Siu,Alan Graham Stuart,Mike Kadour,Jennifer Masters,Kyoko Takano,Tjitske Kleefstra,Nicole de Leeuw,Michael Field,Marie Shaw,Jozef Gecz,Peter Ainsworth,Hanxin Lin,David I. Rodenhiser,Michael J. Friez,Matt Tedder,Jennifer A. Lee,Barbara R. DuPont,Roger E. Stevenson,Steven A. Skinner,Charles E. Schwartz,David Geneviève,Bekim Sadikovic,Bekim Sadikovic +68 more
TL;DR: This study more than doubles the number of published syndromes with DNA methylation episignatures and, most significantly, opens new avenues for accurate diagnosis and clinical assessment in individuals affected by these disorders.
Journal ArticleDOI
Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling
Bekim Sadikovic,Maisa Yoshimoto,Susan Chilton-MacNeill,Paul S. Thorner,Jeremy A. Squire,Maria Zielenska +5 more
TL;DR: The analyses show that the RUNX2 interactome may be constitutively activated in osteosarcoma, and that the downstream intracellular pathways are strongly associated with the regulation of osteoblast differentiation and control of cell cycle and apoptosis in ostea.