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Ben Y. C. Leung
Researcher at Sunnybrook Research Institute
Publications - 23
Citations - 749
Ben Y. C. Leung is an academic researcher from Sunnybrook Research Institute. The author has contributed to research in topics: Microbubbles & Laser. The author has an hindex of 11, co-authored 23 publications receiving 646 citations. Previous affiliations of Ben Y. C. Leung include Sunnybrook Health Sciences Centre & Queen's University.
Papers
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Journal ArticleDOI
In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging
Elizabeth Huynh,Ben Y. C. Leung,Brandon Helfield,Mojdeh Shakiba,Julie-Anne Gandier,Cheng S. Jin,Emma R. Master,Brian C. Wilson,David E. Goertz,Gang Zheng +9 more
TL;DR: This work shows the conversion of microbubbles to nanoparticles using low-frequency ultrasound and shows that this conversion is possible in tumour-bearing mice and could be validated using photoacoustic imaging.
Journal ArticleDOI
Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging
Mansik Jeon,Wentao Song,Elizabeth Huynh,Jung-Ho Kim,Jeesu Kim,Brandon Helfield,Ben Y. C. Leung,David E. Goertz,David E. Goertz,Gang Zheng,Jung-Taek Oh,Jonathan F. Lovell,Chulhong Kim +12 more
TL;DR: Using an MB2 solution that strongly attenuated all photoac acoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control ofphotoacoustic signal generation.
Journal ArticleDOI
In situ 24 kHz coherent imaging of morphology change in laser percussion drilling
Paul J. L. Webster,Joe X. Z. Yu,Ben Y. C. Leung,Mitchell D. Anderson,Victor X. D. Yang,James M. Fraser +5 more
TL;DR: Analysis of sample morphology changes during and between percussion drilling pulses by integrating a low-coherence microscope into a laser micromachining platform shows dramatic differences in the material removal process dependent on pulse duration/peak power and material.
Journal ArticleDOI
Real-time guidance of thermal and ultrashort pulsed laser ablation in hard tissue using inline coherent imaging.
TL;DR: This work monitors incision depth as it progresses, providing feedback to ensure that material removal occurs within a localized target volume, reducing the possibility of undesirable damage to tissues below the incision.
Journal ArticleDOI
Automatic real-time guidance of laser machining with inline coherent imaging
Paul J. L. Webster,Logan G. Wright,Kevin D. Mortimer,Ben Y. C. Leung,Joe X. Z. Yu,James M. Fraser +5 more
TL;DR: Optical coherence imaging can measure hole depth in real-time (>20 kHz) during laser drilling without being blinded by intense machining light or incoherent plasma emissions as mentioned in this paper, which is useful for process development and quality control in a variety of materials including metals, semiconductors, and dielectrics.