Jonathan F. Lovell

TL;DR: This work focuses on the design and implementation of Activatable Photosensitizer Design Considerations, a very simple and straightforward process that simplifies and automates the very labor-intensive and therefore time-heavy and expensive process of Activation Mechanism Selection.

TL;DR: An overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments are provided.

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: Simultaneous measurements of these interactions revealed an ordered series of steps required for outer membrane permeabilization, and with fluorescence techniques and an in vitro system, the combination of tBid and Bax produced dramatic membrane permeability.