Journal ArticleDOI
In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging
Elizabeth Huynh,Ben Y. C. Leung,Brandon Helfield,Mojdeh Shakiba,Julie-Anne Gandier,Cheng S. Jin,Emma R. Master,Brian C. Wilson,David E. Goertz,Gang Zheng +9 more
TLDR
This work shows the conversion of microbubbles to nanoparticles using low-frequency ultrasound and shows that this conversion is possible in tumour-bearing mice and could be validated using photoacoustic imaging.Abstract:
Converting nanoparticles or monomeric compounds into larger supramolecular structures by endogenous or external stimuli is increasingly popular because these materials are useful for imaging and treating diseases. However, conversion of microstructures to nanostructures is less common. Here, we show the conversion of microbubbles to nanoparticles using low-frequency ultrasound. The microbubble consists of a bacteriochlorophyll-lipid shell around a perfluoropropane gas. The encapsulated gas provides ultrasound imaging contrast and the porphyrins in the shell confer photoacoustic and fluorescent properties. On exposure to ultrasound, the microbubbles burst and form smaller nanoparticles that possess the same optical properties as the original microbubble. We show that this conversion is possible in tumour-bearing mice and could be validated using photoacoustic imaging. With this conversion, our microbubble can potentially be used to bypass the enhanced permeability and retention effect when delivering drugs to tumours.read more
Citations
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Journal ArticleDOI
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
TL;DR: It is believed that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve the ability to combat cancers.
Journal ArticleDOI
Nanotechnology for Multimodal Synergistic Cancer Therapy
TL;DR: In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergy therapy.
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Contrast agents for molecular photoacoustic imaging
TL;DR: The physical, chemical and biochemical characteristics of the existing photoacoustic contrast agents are critically reviewed, highlighting key applications and present challenges for molecular PAI.
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Nanomaterials for In Vivo Imaging
TL;DR: This work addresses the physicochemical makeup/design of nanomaterials through the lens of the physical properties that produce contrast signal for the cognate imaging modality-the authors stratify nanommaterials on the basis of their (i) magnetic, (ii) optical, (iii) acoustic, and/or nuclear properties.
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Micro/Nanoparticle-Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation.
TL;DR: It is highly expected that micro/nanoparticle‐augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment and fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.
References
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