Yasumasa Nishito

TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.

TL;DR: The findings indicate that the pathological process associated with p62 accumulation results in hyperactivation of Nrf2 and delineates unexpected roles of selective autophagy in controlling the transcription of cellular defence enzyme genes.

TL;DR: It is shown that Rif1 (Rap1‐interacting‐factor‐1), originally identified as a telomere‐binding factor in yeast, is a critical determinant of the replication timing programme in human cells.

TL;DR: In this article, the authors reveal the molecular mechanism of p62/Sqstm1-dependent malignant progression, and suggest that molecular targeting of P62/sqstmm1 represents a potential chemotherapeutic approach against hepatocellular carcinoma (HCC).

TL;DR: It is shown that PNPLA1, an enzyme expressed in differentiated keratinocytes, plays a crucial role in the biosynthesis of ω-O-acylceramide, a lipid component essential for skin barrier and may contribute to novel therapeutic strategies for treatment of epidermal barrier defects.