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Benjamin Gaston
Researcher at Indiana University
Publications - 30
Citations - 1524
Benjamin Gaston is an academic researcher from Indiana University. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 7, co-authored 21 publications receiving 1268 citations. Previous affiliations of Benjamin Gaston include Indiana University – Purdue University Indianapolis & Cleveland Clinic.
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Journal ArticleDOI
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Wendy C. Moore,Eugene R. Bleecker,Douglas Curran-Everett,Serpil C. Erzurum,Bill T. Ameredes,Leonard B. Bacharier,William J. Calhoun,Mario Castro,Kian Fan Chung,Melissa P. Clark,Raed A. Dweik,Anne M. Fitzpatrick,Benjamin Gaston,Mark Hew,Iftikhar Hussain,Nizar N. Jarjour,Elliot Israel,Bruce D. Levy,James Murphy,Stephen P. Peters,W. Gerald Teague,Deborah A. Meyers,William W. Busse,Sally E. Wenzel,Sally E. Wenzel,Sally E. Wenzel +25 more
TL;DR: Severe asthma is characterized by abnormal lung function that is responsive to bronchodilators, a history of sinopulmonary infections, persistent symptoms, and increased health care utilization.
Journal ArticleDOI
Use of Exhaled Nitric Oxide Measurement to Identify a Reactive, at-Risk Phenotype among Patients with Asthma
Raed A. Dweik,Raed A. Dweik,R.L. Sorkness,Sally E. Wenzel,Jeffrey P. Hammel,Douglas Curran-Everett,Suzy A. A. Comhair,Suzy A. A. Comhair,Eugene R. Bleecker,William W. Busse,William J. Calhoun,Mario Castro,Kian Fan Chung,Elliot Israel,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,Gerald Teague,Benjamin Gaston,Serpil C. Erzurum,Serpil C. Erzurum +20 more
TL;DR: Grouping of asthma by Fe(NO) provides an independent classification of asthma severity, and among patients with severe asthma identifies the most reactive and worrisome asthma phenotype.
Journal ArticleDOI
Correlation of Systemic Superoxide Dismutase Deficiency to Airflow Obstruction in Asthma
Suzy A. A. Comhair,Kristin Ricci,Mercedes E. Arroliga,Abigail R. Lara,Raed A. Dweik,Wei Song,Stanley L. Hazen,Eugene R. Bleecker,W. W. Busse,Kian Fan Chung,Benjamin Gaston,Annette T. Hastie,Mark Hew,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,W. Gerald Teague,Sally E. Wenzel,Serpil C. Erzurum +18 more
TL;DR: Findings are consistent with greater oxidant stress in asthma leading to greater inactivation of SOD, which likely amplifies inflammation and progressive airflow obstruction.
Journal ArticleDOI
Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.
Mehdi Baratchian,Jeffrey M. McManus,Mike Berk,Fumihiko Nakamura,Sanjay Mukhopadhyay,Weiling Xu,Serpil C. Erzurum,Serpil C. Erzurum,Judy Drazba,John W. Peterson,Eric A. Klein,Benjamin Gaston,Nima Sharifi,Nima Sharifi +13 more
TL;DR: In this article, the authors investigated the sex-associated TMPRSS2 and ACE2 expression in human and mouse lungs and interrogated the possibility of pharmacologic modification of their expression with anti-androgens.
Journal ArticleDOI
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.
Xingnan Li,Stephanie A. Christenson,Brian D. Modena,Huashi Li,William W. Busse,Mario Castro,Loren C. Denlinger,Serpil C. Erzurum,John V. Fahy,Benjamin Gaston,Annette T. Hastie,Elliot Israel,Nizar N. Jarjour,Bruce D. Levy,Wendy C. Moore,Prescott G. Woodruff,Naftali Kaminski,Sally E. Wenzel,Eugene R. Bleecker,Deborah A. Meyers +19 more
TL;DR: By using a unique set of gene expression data from lung cells obtained using bronchoscopy from comprehensively characterized asthma subjects, it is shown that SNPs in GSDMB is a functional gene for both asthma susceptibility and severity.