L
Leonard B. Bacharier
Researcher at University of Washington
Publications - 193
Citations - 14384
Leonard B. Bacharier is an academic researcher from University of Washington. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 54, co-authored 130 publications receiving 12771 citations. Previous affiliations of Leonard B. Bacharier include Washington University in St. Louis & Harvard University.
Papers
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Journal ArticleDOI
Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
Jan Lötvall,Cezmi A. Akdis,Leonard B. Bacharier,Leif Bjermer,Thomas B. Casale,Adnan Custovic,Robert F. Lemanske,Andrew J. Wardlaw,Sally E. Wenzel,Paul A. Greenberger +9 more
TL;DR: Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested and how these new definitions can be used in clinical study design and drug development to target existing and novel therapies to patients most likely to benefit are proposed.
Journal ArticleDOI
Long-term inhaled corticosteroids in preschool children at high risk for asthma.
Theresa W. Guilbert,Wayne J. Morgan,Robert S. Zeiger,Robert S. Zeiger,David T. Mauger,Susan J. Boehmer,Stanley J. Szefler,Leonard B. Bacharier,R.F. Lemanske,Robert C. Strunk,David B. Allen,Gordon R. Bloomberg,Gregory P. Heldt,Marzena E. Krawiec,Gary L. Larsen,A.H. Liu,Vernon M. Chinchilli,Christine A. Sorkness,Lynn M. Taussig,Fernando D. Martinez +19 more
TL;DR: In preschool children at high risk for asthma, two years of inhaled-corticosteroid therapy did not change the development of asthma symptoms or lung function during a third, treatment-free year, and these findings do not provide support for a subsequent disease-modifying effect of inhaling corticosteroids after the treatment is discontinued.
Journal ArticleDOI
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Wendy C. Moore,Eugene R. Bleecker,Douglas Curran-Everett,Serpil C. Erzurum,Bill T. Ameredes,Leonard B. Bacharier,William J. Calhoun,Mario Castro,Kian Fan Chung,Melissa P. Clark,Raed A. Dweik,Anne M. Fitzpatrick,Benjamin Gaston,Mark Hew,Iftikhar Hussain,Nizar N. Jarjour,Elliot Israel,Bruce D. Levy,James Murphy,Stephen P. Peters,W. Gerald Teague,Deborah A. Meyers,William W. Busse,Sally E. Wenzel,Sally E. Wenzel,Sally E. Wenzel +25 more
TL;DR: Severe asthma is characterized by abnormal lung function that is responsive to bronchodilators, a history of sinopulmonary infections, persistent symptoms, and increased health care utilization.
Journal ArticleDOI
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report
Leonard B. Bacharier,A. L. Boner,K-H. Carlsen,Philippe Eigenmann,Thomas Frischer,M. Götz,Peter Joseph Benedict Helms,John F. Hunt,Andrew H. Liu,Nikolaos G. Papadopoulos,Thomas A.E. Platts-Mills,Petr Pohunek,F. E. R. Simons,Erkka Valovirta,Ulrich Wahn,J. Wildhaber +15 more
TL;DR: This consensus report recommends strategies that include pharmacological treatment, allergen and trigger avoidance and asthma education that are recommended for clinical practice in Europe as well as in North America.
Journal ArticleDOI
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
Stanley J. Szefler,Brenda R. Phillips,Fernando D. Martinez,Vernon M. Chinchilli,Robert F. Lemanske,Robert C. Strunk,Robert S. Zeiger,Robert S. Zeiger,Gary L. Larsen,Joseph D. Spahn,Leonard B. Bacharier,Gordon R. Bloomberg,Theresa W. Guilbert,Gregory P. Heldt,Wayne J. Morgan,Mark H. Moss,Christine A. Sorkness,Lynn M. Taussig +17 more
TL;DR: Whether responses to ICSs and LTRAs are concordant for individuals or whether asthmatic patients who do not respond to one medication respond to the other is investigated.