Bernard de Massy

TL;DR: The identification of new players in DSB repair processes has allowed the delineation of recombination pathways that have two major outcomes, crossovers and non-crossovers, which have distinct mechanistic roles and consequences for genome evolution.

TL;DR: It is shown that transcription of the genome is substantially more widespread in the testis than in other organs across representative mammals, and it is revealed that meiotic spermatocytes and especially postmeiotic round sperMatids have remarkably diverse transcriptomes, which explains the high transcriptome complexity of the testes as a whole.

TL;DR: The recent advances in the components required for DSB formation and localization in the various model organisms in which these studies have been performed are reviewed.

TL;DR: It is shown that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes, and it is inferred that selective stabilization of key recombination proteins is a fundamental feature of meiotic crossover control.

TL;DR: The chromatin signatures of the Psmb9 and Hlx1 hotspots provide a basis for understanding the distribution of meiotic recombination and suggest that H3K4Me3 and H4 hyperacetylation are common features of DSB formation and repair, respectively.