H
Hongcang Gu
Researcher at Broad Institute
Publications - 72
Citations - 17287
Hongcang Gu is an academic researcher from Broad Institute. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 39, co-authored 67 publications receiving 15291 citations. Previous affiliations of Hongcang Gu include University of Oklahoma Health Sciences Center & Harvard University.
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Journal ArticleDOI
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.
Journal ArticleDOI
Charting a dynamic DNA methylation landscape of the human genome
Michael J. Ziller,Hongcang Gu,Fabian Müller,Julie Donaghey,Julie Donaghey,Linus T.-Y. Tsai,Oliver Kohlbacher,Philip L. De Jager,Philip L. De Jager,Evan D. Rosen,Evan D. Rosen,David A. Bennett,Bradley E. Bernstein,Bradley E. Bernstein,Andreas Gnirke,Alexander Meissner,Alexander Meissner +16 more
TL;DR: Although in theory every CpG can change its methylation state, the results suggest that only a fraction does so as part of coordinated regulatory programs, which highlights the general inefficiency of whole-genome bisulphite sequencing.
Journal ArticleDOI
Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals
Benjamin R. Carone,Lucas Fauquier,Naomi Habib,Jeremy M. Shea,Caroline E. Hart,Ruowang Li,Christoph Bock,Christoph Bock,Chengjian Li,Hongcang Gu,Phillip D. Zamore,Alexander Meissner,Alexander Meissner,Zhiping Weng,Hans A. Hofmann,Nir Friedman,Oliver J. Rando +16 more
TL;DR: It is indicated that parental diet can affect cholesterol and lipid metabolism in offspring and define a model system to study environmental reprogramming of the heritable epigenome.
Journal ArticleDOI
Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines
Christoph Bock,Evangelos Kiskinis,Evangelos Kiskinis,Griet Verstappen,Griet Verstappen,Hongcang Gu,Gabriella L. Boulting,Zachary D. Smith,Zachary D. Smith,Michael J. Ziller,Michael J. Ziller,Gist F. Croft,Mackenzie W. Amoroso,Derek H. Oakley,Andreas Gnirke,Kevin Eggan,Kevin Eggan,Alexander Meissner,Alexander Meissner +18 more
TL;DR: This resource enabled us to assess the epigenetic and transcriptional similarity of ES and iPS cells and to predict the differentiation efficiency of individual cell lines, and yields a scorecard for quick and comprehensive characterization of pluripotent cell lines.
Journal ArticleDOI
Dnmt3a is essential for hematopoietic stem cell differentiation.
Grant A. Challen,Deqiang Sun,Mira Jeong,Min Luo,Jaroslav Jelinek,Jonathan S. Berg,Jonathan S. Berg,Christoph Bock,Aparna Vasanthakumar,Hongcang Gu,Yuanxin Xi,Shoudan Liang,Yue Lu,Gretchen J. Darlington,Alexander Meissner,Jean Pierre J. Issa,Lucy A. Godley,Wei Li,Margaret A. Goodell +18 more
TL;DR: Using conditional ablation, it is shown that Dnmt3a loss progressively impairs hematopoietic stem cell differentiation over serial transplantation, while simultaneously expanding HSC numbers in the bone marrow.