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Anamaria Necsulea
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 28
Citations - 4026
Anamaria Necsulea is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Gene & Hox gene. The author has an hindex of 18, co-authored 26 publications receiving 3480 citations. Previous affiliations of Anamaria Necsulea include Swiss Institute of Bioinformatics & University of Lyon.
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Journal ArticleDOI
The evolution of gene expression levels in mammalian organs
David Brawand,Magali Soumillon,Magali Soumillon,Anamaria Necsulea,Anamaria Necsulea,Philippe Julien,Philippe Julien,Gábor Csárdi,Gábor Csárdi,Patrick Harrigan,Manuela Weier,Angélica Liechti,Ayinuer Aximu-Petri,Martin Kircher,Frank W. Albert,Ulrich Zeller,Philipp Khaitovich,Frank Grützner,Sven Bergmann,Sven Bergmann,Rasmus Nielsen,Rasmus Nielsen,Svante Pääbo,Henrik Kaessmann +23 more
TL;DR: It is shown that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation.
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The evolution of lncRNA repertoires and expression patterns in tetrapods
Anamaria Necsulea,Magali Soumillon,Maria Warnefors,Angélica Liechti,Tasman Daish,Ulrich Zeller,Julie C. Baker,Frank Grützner,Henrik Kaessmann +8 more
TL;DR: It is found that lncRNAs, in particular ancient ones, are in general actively regulated and may function predominantly in embryonic development, and an evolutionarily conserved co-expression network is reconstructed.
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Cellular Source and Mechanisms of High Transcriptome Complexity in the Mammalian Testis
Magali Soumillon,Magali Soumillon,Anamaria Necsulea,Anamaria Necsulea,Manuela Weier,David Brawand,David Brawand,Xiaolan Zhang,Hongcang Gu,Pauline Barthès,Maria Kokkinaki,Serge Nef,Andreas Gnirke,Martin Dym,Bernard de Massy,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Henrik Kaessmann,Henrik Kaessmann +18 more
TL;DR: It is shown that transcription of the genome is substantially more widespread in the testis than in other organs across representative mammals, and it is revealed that meiotic spermatocytes and especially postmeiotic round sperMatids have remarkably diverse transcriptomes, which explains the high transcriptome complexity of the testes as a whole.
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Parallel adaptations to high temperatures in the Archaean eon
Bastien Boussau,Samuel Blanquart,Anamaria Necsulea,Nicolas Lartillot,Nicolas Lartillot,Manolo Gouy +5 more
TL;DR: In this paper, both rRNA and protein sequences analysed with advanced, realistic models of molecular evolution provide independent support for two environmental temperature-related phases during the evolutionary history of the tree of life.
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Evolutionary dynamics of coding and non-coding transcriptomes
TL;DR: This work reviews the initial wave of the new generation of comparative transcriptomic studies in mammals and vertebrate outgroup species in the context of earlier work and provides intriguing new clues to the regulatory basis and phenotypic implications of evolutionary gene expression changes.