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Bernard J. Pope
Researcher at University of Melbourne
Publications - 73
Citations - 2535
Bernard J. Pope is an academic researcher from University of Melbourne. The author has contributed to research in topics: Massive parallel sequencing & Cancer. The author has an hindex of 20, co-authored 65 publications receiving 1997 citations. Previous affiliations of Bernard J. Pope include Monash University, Clayton campus & Monash University.
Papers
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Journal ArticleDOI
SRST2: Rapid genomic surveillance for public health and hospital microbiology labs
Michael Inouye,Harriet Dashnow,Harriet Dashnow,Lesley Raven,Mark B. Schultz,Bernard J. Pope,Bernard J. Pope,Takehiro Tomita,Justin Zobel,Kathryn E. Holt +9 more
TL;DR: This work presents SRST2, a read mapping-based tool for fast and accurate detection of genes, alleles and multi-locus sequence types (MLST) from WGS data, which is highly accurate and outperforms assembly-based methods in terms of both gene detection and allele assignment.
Journal ArticleDOI
MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes
Helena Bujalka,Matthias Koenning,Stacey Jackson,Victoria M. Perreau,Bernard J. Pope,Curtis M. Hay,Stanlislaw Mitew,Andrew F. Hill,Q. Richard Lu,Michael Wegner,Rajini Srinivasan,John Svaren,Melanie Willingham,Ben A. Barres,Ben Emery,Ben Emery +15 more
TL;DR: Oligodendrocyte development and myelination rely on an unusual membrane-associated transcription factor that shares functional domains with bacteriophage proteins.
Journal ArticleDOI
Rare mutations in XRCC2 increase the risk of breast cancer
Daniel J. Park,Fabienne Lesueur,Tu Nguyen-Dumont,Maroulio Pertesi,Fabrice Odefrey,Fleur Hammet,Susan L. Neuhausen,Esther M. John,Esther M. John,Irene L. Andrulis,Mary Beth Terry,M. Daly,Saundra S. Buys,F. Le Calvez-Kelm,Andrew Lonie,Bernard J. Pope,Helen Tsimiklis,Catherine Voegele,F.M. Hilbers,Nicoline Hoogerbrugge,Alicia Barroso,Ana Osorio,Graham G. Giles,Peter Devilee,Javier Benítez,John L. Hopper,Sean V. Tavtigian,David E. Goldgar,Melissa C. Southey +28 more
TL;DR: The identification of XRCC2 as a breast cancer susceptibility gene thus increases the proportion of breast cancers that are associated with homologous recombination-DNA-repair dysfunction and Fanconi anemia and could therefore benefit from specific targeted treatments such as PARP (poly ADP ribose polymerase) inhibitors.
Posted ContentDOI
SRST2: Rapid genomic surveillance for public health and hospital microbiology labs
Michael Inouye,Harriet Dashnow,Lesley Raven,Mark B. Schultz,Bernard J. Pope,Takehiro Tomita,Justin Zobel,Kathryn E. Holt +7 more
TL;DR: Using >900 genomes from common pathogens, SRST2 is highly accurate and outperforms assembly-based methods in terms of both gene detection and allele assignment and represents a powerful tool for rapidly extracting clinically useful information from raw WGS data.
Journal ArticleDOI
Bpipe : A Tool for Running and Managing Bioinformatics Pipelines
TL;DR: Bpipe is a simple, dedicated programming language for defining and executing bioinformatics pipelines that is fully self-contained and cross-platform, making it very easy to adopt and deploy into existing environments.