M
M. Daly
Researcher at Fox Chase Cancer Center
Publications - 16
Citations - 1878
M. Daly is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 15, co-authored 16 publications receiving 1806 citations.
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Journal ArticleDOI
International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers.
Kelly A. Metcalfe,Daphna Birenbaum-Carmeli,Jan Lubinski,Jacek Gronwald,Henry T. Lynch,Pål Møller,Parviz Ghadirian,William D. Foulkes,Jan Klijn,Eitan Friedman,Eitan Friedman,Charmaine Kim-Sing,Peter Ainsworth,B. Rosen,Susan M. Domchek,T Wagner,Nadine Tung,Siranoush Manoukian,Fergus J. Couch,Ping Sun,Steven A. Narod,M. Daly,Howard M. Saal,Kevin Sweet,Dominique Stoppa Lyonnet,A. Eisen,G. Rennen,J. McLennan,Ruth Gershoni-Baruch,Judy Garber,Shelly Cummings,J. N. Weitzel,Beth Y. Karlan,Raluca N. Kurz,Wendy McKinnon,Marie E. Wood,Dawna Gilchrist,Albert E. Chudley,Michael P. Osborne,David A. Fishman,W. S. Meschino,Edmond G. Lemire,Christine Maugard,Gordon B. Mills,Sofia D. Merajver,Daniel Rayson,J. M. Collee +46 more
TL;DR: Nearly one‐half of the women at risk for breast cancer had taken no preventive option, relying solely on screening, and there were large differences in the uptake of the different preventive options by country of residence.
Journal ArticleDOI
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families
Patricia N. Tonin,Barbara L. Weber,Kenneth Offit,Fergus J. Couch,Timothy R. Rebbeck,Susan L. Neuhausen,Andrew K. Godwin,M. Daly,J Wagner-Costalos,David B. Berman,Generosa Grana,Ellen Fox,Michael F. Kane,Richard D. Kolodner,Michael Krainer,Daniel A. Haber,Jeffery P. Struewing,Ellen Warner,Bruce R. Rosen,Caryn Lerman,Beth N. Peshkin,Larry Norton,Olga Serova,William D. Foulkes,Judy Garber +24 more
TL;DR: Two founding mutations in BRCa1 and BRCA2 are responsible for a large proportion of Jewish families with the breast-ovarian cancer syndrome.
Journal ArticleDOI
Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2
Helena Jernström,Caryn Lerman,Parviz Ghadirian,Henry T. Lynch,Barbara L. Weber,Judy Garber,M. Daly,Olufunmilayo I. Olopade,William D. Foulkes,Ellen Warner,Jean-Sébastien Brunet,Steven A. Narod +11 more
TL;DR: Whether pregnancy is a risk factor for hereditary breast cancer is established and an early first pregnancy does not confer protection for carriers of BRCA1 or BRCa2 mutations.
Journal ArticleDOI
Breast-feeding and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
Helena Jernström,Jan Lubinski,Henry T. Lynch,Parviz Ghadirian,Susan L. Neuhausen,Claudine Isaacs,Barbara L. Weber,Douglas E. Horsman,Bruce R. Rosen,William D. Foulkes,Eitan Friedman,Ruth Gershoni-Baruch,Peter Ainsworth,M. Daly,Judy Garber,Håkan Olsson,Ping Sun,Steven A. Narod +17 more
TL;DR: Women with deleterious BRCA1 mutations who breast-fed for a cumulative total of more than 1 year had a statistically significantly reduced risk of breast cancer.
Journal ArticleDOI
Rare mutations in XRCC2 increase the risk of breast cancer
Daniel J. Park,Fabienne Lesueur,Tu Nguyen-Dumont,Maroulio Pertesi,Fabrice Odefrey,Fleur Hammet,Susan L. Neuhausen,Esther M. John,Esther M. John,Irene L. Andrulis,Mary Beth Terry,M. Daly,Saundra S. Buys,F. Le Calvez-Kelm,Andrew Lonie,Bernard J. Pope,Helen Tsimiklis,Catherine Voegele,F.M. Hilbers,Nicoline Hoogerbrugge,Alicia Barroso,Ana Osorio,Graham G. Giles,Peter Devilee,Javier Benítez,John L. Hopper,Sean V. Tavtigian,David E. Goldgar,Melissa C. Southey +28 more
TL;DR: The identification of XRCC2 as a breast cancer susceptibility gene thus increases the proportion of breast cancers that are associated with homologous recombination-DNA-repair dysfunction and Fanconi anemia and could therefore benefit from specific targeted treatments such as PARP (poly ADP ribose polymerase) inhibitors.