Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Raffaele Teperino,Sabine Amann,Martina Bayer,Sean L. McGee,Andrea Loipetzberger,Timothy Connor,Carsten Jaeger,Bernd Kammerer,Lilli Winter,Gerhard Wiche,Kevin Dalgaard,Madhan Selvaraj,Michael Gaster,Robert S. Lee-Young,Mark A. Febbraio,Claude Knauf,Patrice D. Cani,Fritz Aberger,Josef M. Penninger,J. Andrew Pospisilik,Harald Esterbauer +20 more
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TLDR
It is shown that hedgehog signaling rewires cellular metabolism and is identified a cilium-dependent Smo-Ca(2+)-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility.About:
This article is published in Cell.The article was published on 2012-10-12 and is currently open access. It has received 232 citations till now. The article focuses on the topics: Cyclopamine & Hedgehog signaling pathway.read more
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Journal ArticleDOI
The mechanisms of Hedgehog signalling and its roles in development and disease.
TL;DR: Novel biological insights are revealed into the function of HH lipidation in the secretion and transport of this ligand and details of the signal transduction pathway, which involves Patched 1, Smoothened and GLI proteins, as well as, in vertebrates, primary cilia.
Journal ArticleDOI
Adaptive thermogenesis in adipocytes: Is beige the new brown?
TL;DR: A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.
Book ChapterDOI
Analysis and Interpretation of Microplate-Based Oxygen Consumption and pH Data
TL;DR: This chapter provides a description of the standard parameters for measuring respiration in intact cells, a framework for data analysis and normalization, and examples of measuring resppiration in permeabilized cells to follow up results observed with intact cells.
Journal ArticleDOI
NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk.
Stefano Ballestri,Fabio Nascimbeni,Enrica Baldelli,Alessandra Marrazzo,Dante Romagnoli,Amedeo Lonardo +5 more
TL;DR: Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma associated with striking systemic features and excess cardiovascular and liver-related mortality.
Journal ArticleDOI
Proteomics of Primary Cilia by Proximity Labeling
David U. Mick,Rachel B. Rodrigues,Ryan D. Leib,Christopher M. Adams,Allis Chien,Steven P. Gygi,Maxence V. Nachury +6 more
TL;DR: This work demonstrates that proximity labeling can be applied to proteomics of non-membrane-enclosed organelles and suggests that proteomics profiling of cilia will enable a rapid and powerful characterization of ciliopathies.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Mutations affecting segment number and polarity in Drosophila
TL;DR: The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
Journal ArticleDOI
AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity
Carles Cantó,Zachary Gerhart-Hines,Jerome N. Feige,Marie Lagouge,Liliana Noriega,Liliana Noriega,Jill C. Milne,Peter J. Elliott,Pere Puigserver,Johan Auwerx,Johan Auwerx +10 more
TL;DR: It is demonstrated that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1.
Journal ArticleDOI
Cancer Cell Metabolism: Warburg and Beyond
TL;DR: The Warburg effect of aerobic glycolysis is re-examine and a framework for understanding its contribution to the altered metabolism of cancer cells is established.
Journal ArticleDOI
Inflammatory links between obesity and metabolic disease.
Carey N. Lumeng,Alan R. Saltiel +1 more
TL;DR: This Review highlights the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation and underscores how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.
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