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Bernd Timmermann
Researcher at Max Planck Society
Publications - 161
Citations - 27435
Bernd Timmermann is an academic researcher from Max Planck Society. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 45, co-authored 146 publications receiving 19299 citations. Previous affiliations of Bernd Timmermann include Max Delbrück Center for Molecular Medicine & University of Bergen.
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Wild tobacco genomes reveal the evolution of nicotine biosynthesis
Shuqing Xu,Thomas Brockmoeller,Aura Navarro-Quezada,Heiner Kuhl,Klaus Gase,Zhihao Ling,Wenwu Zhou,Christoph Kreitzer,Mario Stanke,Haibao Tang,Eric Lyons,Priyanka Pandey,Shree P. Pandey,Bernd Timmermann,Emmanuel Gaquerel,Ian T. Baldwin +15 more
TL;DR: Sequenced and assembled genomes of two wild tobaccos provide evidence that TEs and gene duplications facilitated the emergence of a key metabolic innovation relevant to plant fitness.
Journal ArticleDOI
Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region.
Markus Draaken,Friederike Baudisch,Bernd Timmermann,Heiner Kuhl,Martin Kerick,Judith Proske,Lars Wittler,Tracie Pennimpede,Anne Karoline Ebert,Wolfgang Rösch,Raimund Stein,Enrika Bartels,Catharina von Lowtzow,Thomas M. Boemers,Stefan Herms,Stefan Herms,John P. Gearhart,Yegappan Lakshmanan,Christina Clementsson Kockum,Gundela Holmdahl,Göran Läckgren,Agnetha Nordenskjöld,Agnetha Nordenskjöld,Simeon A. Boyadjiev,Bernhard G. Herrmann,Markus M. Nöthen,Michael Ludwig,Heiko Reutter,Heiko Reutter +28 more
TL;DR: The data suggest that duplication of 22q11.21 increases CBE risk and implicate a phenocritical region in disease formation in an extended case-control sample.
Posted ContentDOI
Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites
Jesse V. Veenvliet,Adriano Bolondi,Helene Kretzmer,Leah Haut,Manuela Scholze-Wittler,Dennis Schifferl,Frederic Koch,Milena Pustet,Simon Heimann,René Buschow,Lars Wittler,Bernd Timmermann,Alexander Meissner,Bernhard G. Herrmann,Bernhard G. Herrmann +14 more
TL;DR: In this paper, a trunk-like-structures (TLS) with precursors of spinal cord, bone and muscle from stem cells in a dish is presented. But the authors do not show that TLS lacking Tbx6 form ectopic neural tubes, mirroring the embryonic mutant phenotype.
Journal ArticleDOI
Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication
Sascha Young Kupke,Lam-Ha Ly,Stefan T. Börno,Alexander Ruff,Bernd Timmermann,Martin Vingron,Stefan A. Haas,Udo Reichl,Udo Reichl +8 more
TL;DR: These insights advance single-cell virology research toward the elucidation of the complex multi-parametric origin of the large cell-to-cell heterogeneity in virus infections.
The metabolic growth limitations of petite cells lacking the mitochondrial genome.
Jakob Vowinckel,Johannes Hartl,Johannes Hartl,Hans Marx,Martin Kerick,Martin Kerick,Kathrin Runggatscher,Markus A. Keller,Markus A. Keller,Michael Mülleder,Michael Mülleder,Michael Mülleder,Jason Day,Manuela Weber,Mark Rinnerthaler,Jason S. L. Yu,Simran Kaur Aulakh,Andrea Lehmann,Diethard Mattanovich,Bernd Timmermann,Nianshu Zhang,Cory D. Dunn,Cory D. Dunn,James I. MacRae,Michael Breitenbach,Markus Ralser,Markus Ralser,Markus Ralser +27 more
TL;DR: In this article, a combination of molecular genetics and omics approaches was used to demonstrate the evolution of fast growth overcomes these amino acid deficiencies, by alleviating a perturbation in mitochondrial iron metabolism and by restoring a defect in the mitochondrial tricarboxylic acid cycle, caused by aconitase inhibition.