Bernd Timmermann

TL;DR: It is shown that Liebenberg syndrome, an autosomal-dominant upper-limb malformation, shows features of a homeotic limb transformation in which the arms have acquired morphological characteristics of a leg.

TL;DR: The generation and use of an engineered, methylation depleted but maintenance competent mouse ES cell line is reported and a surprisingly ubiquitous nuclear activity of dCas9-methyltransferases is found, finding ubiquitous off-target activity within a highly methylated genome.

TL;DR: By presenting higher frequency for 37,384 novel or known rare variants, Iranome database can improve the power of molecular diagnosis and attainable clinical information makes this database a good resource for classifying pathogenicity of rare variants.

TL;DR: It is shown that chromosomal inversions that relocate a limb enhancer can establish asymmetric stripes of the enhancer with downstream genes, resulting in ectopic gene expression and limb phenotypes, and architectural stripes are a frequent feature of developmental three-dimensional genome architecture often associated with active enhancers.

TL;DR: A yeast two-hybrid interaction screening approach involving short-read second-generation sequencing with improved sensitivity and a quantitative scoring readout allowing rapid interaction validation to investigate enzymes involved in protein methylation, a largely unexplored post-translational modification.