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Bernd Timmermann
Researcher at Max Planck Society
Publications - 161
Citations - 27435
Bernd Timmermann is an academic researcher from Max Planck Society. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 45, co-authored 146 publications receiving 19299 citations. Previous affiliations of Bernd Timmermann include Max Delbrück Center for Molecular Medicine & University of Bergen.
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Journal ArticleDOI
Global delay in nascent strand DNA methylation.
Jocelyn Charlton,Timothy L. Downing,Timothy L. Downing,Timothy L. Downing,Zachary D. Smith,Zachary D. Smith,Hongcang Gu,Kendell Clement,Kendell Clement,Ramona Pop,Veronika Akopian,Sven Klages,David Santos,Alexander M. Tsankov,Alexander M. Tsankov,Bernd Timmermann,Michael J. Ziller,Evangelos Kiskinis,Andreas Gnirke,Alexander Meissner +19 more
TL;DR: The data suggest that heterogeneous methylation largely reflects asynchronous proliferation, but is intrinsic to actively engaged cis-regulatory elements and cancer, but cancer cells and active transcription factor binding sites preserve heterogeneity even after cell cycle arrest.
Journal ArticleDOI
Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.
Hans Binder,Lydia Hopp,Michal R. Schweiger,Michal R. Schweiger,Steve Hoffmann,Frank Jühling,Frank Jühling,Frank Jühling,Martin Kerick,Martin Kerick,Bernd Timmermann,Susann Siebert,Susann Siebert,Christina Grimm,Christina Grimm,Lilit Nersisyan,Arsen Arakelyan,Maria Herberg,Peter Buske,Henry Loeffler-Wirth,Maciej Rosolowski,Christoph Engel,Jens Przybilla,Martin Peifer,Nicolaus Friedrichs,Gabriela Moeslein,Margarete Odenthal,Michelle Hussong,Michelle Hussong,Sophia Peters,Stefanie Holzapfel,Jacob Nattermann,Robert Hueneburg,Wolff Schmiegel,Brigitte Royer-Pokora,Stefan Aretz,Michael Kloth,Matthias Kloor,Matthias Kloor,Reinhard Buettner,Jörg Galle,Markus Loeffler +41 more
TL;DR: It is hypothesized that G1 tumours are edited for escape from a highly immunogenic microenvironment via loss of HLA presentation and T‐cell exhaustion, and in contrast, G2 tumours seem to develop in a less immunogenicmicroenvironment where tumour‐promoting inflammation parallels tumourigenesis.
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Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator
Lila Allou,Lila Allou,Sara Balzano,Andreas Magg,Andreas Magg,Mathieu Quinodoz,Mathieu Quinodoz,Beryl Royer-Bertrand,Robert Schöpflin,Robert Schöpflin,Wing Lee Chan,Carlos E. Speck-Martins,Daniel R. Carvalho,Luciano Farage,Charles Marques Lourenço,Regina Albuquerque,Srilakshmi Rajagopal,Sheela Nampoothiri,Belinda Campos-Xavier,Carole Chiesa,Florence Niel-Bütschi,Lars Wittler,Bernd Timmermann,Malte Spielmann,Malte Spielmann,Malte Spielmann,Michael I. Robson,Alessa R. Ringel,Verena Heinrich,Giulia Cova,Giulia Cova,Guillaume Andrey,Guillaume Andrey,Cesar Augusto Prada-Medina,Rosanna Pescini-Gobert,Sheila Unger,Luisa Bonafé,Phillip Grote,Carlo Rivolta,Stefan Mundlos,Stefan Mundlos,Andrea Superti-Furga +41 more
TL;DR: In this paper, the authors identify homozygous 27-63-kilobase deletions located 300kilobases upstream of the engrailed-1 gene (EN1) in patients with a complex limb malformation featuring mesomelic shortening, syndactyly and ventral nails (dorsal dimelia).
Journal ArticleDOI
Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases
Isabel Spier,Dmitriy Drichel,Martin Kerick,Martin Kerick,Jutta Kirfel,Sukanya Horpaopan,Andreas Laner,Stefanie Holzapfel,Sophia Peters,Ronja Adam,Bixiao Zhao,Tim Becker,Richard P. Lifton,Sven Perner,Per Hoffmann,Glen Kristiansen,Bernd Timmermann,Markus M. Nöthen,Elke Holinski-Feder,Michal R. Schweiger,Michal R. Schweiger,Stefan Aretz +21 more
TL;DR: A high prevalence of pathogenic mosaic APC mutations below the detection thresholds of routine diagnostics in adenomatous polyposis is indicated, even if high-coverage sequencing of leucocyte DNA alone is taken into account.
Journal ArticleDOI
Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells.
Huajie Bu,Michal R. Schweiger,Thomas Manke,Andrea Wunderlich,Bernd Timmermann,Martin Kerick,Lorenza Pasqualini,Erald Shehu,Christian Fuchsberger,Andrew C.B. Cato,Helmut Klocker +10 more
TL;DR: The effect of androgens and oestrogens on the expression of anterior gradient 2 and anterior gradient 3, comprising two highly‐related genes encoding secretory proteins that are expressed in prostate cancer and one of which has been associated with tumour metastasis, is analyzed.