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Bernd Timmermann
Researcher at Max Planck Society
Publications - 161
Citations - 27435
Bernd Timmermann is an academic researcher from Max Planck Society. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 45, co-authored 146 publications receiving 19299 citations. Previous affiliations of Bernd Timmermann include Max Delbrück Center for Molecular Medicine & University of Bergen.
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Journal ArticleDOI
Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells
Radmila Feldmann,Cornelius Fischer,Vitam Kodelja,Sarah Behrens,Stefan A. Haas,Martin Vingron,Bernd Timmermann,Anne Geikowski,Sascha Sauer +8 more
TL;DR: These observations identified highly integrated LXRα ligand-dependent transcriptional networks, including the APOE/C1/C4/C2-gene cluster, which contribute to the reversal of cholesterol efflux and the dampening of inflammation processes in foam cells to prevent atherogenesis.
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Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance
Sabrina Grasse,Matthias Lienhard,Steffen Frese,Martin Kerick,Anne Steinbach,Christina Grimm,Michelle Hussong,Jana Rolff,Michael Becker,Felix Dreher,Uwe Schirmer,Stefan Boerno,Anna Ramisch,Gunda Leschber,Bernd Timmermann,Christian Grohé,Heike Lüders,Martin Vingron,Iduna Fichtner,Sebastian Klein,Margarete Odenthal,Reinhard Büttner,Hans Lehrach,Holger Sültmann,Ralf Herwig,Michal R. Schweiger +25 more
TL;DR: Differential methylation patterns from primary lung cancer and PDX-derived cancers to be very similar, albeit with a lower degree of differential methylation in primary tumors, according to an epigenome-wide sequencing approach.
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The mole genome reveals regulatory rearrangements associated with adaptive intersexuality
Francisca M. Real,Francisca M. Real,Stefan A. Haas,Paolo Franchini,Peiwen Xiong,Oleg Simakov,Heiner Kuhl,Robert Schöpflin,Robert Schöpflin,David Heller,Mohammad Hossein Moeinzadeh,Verena Heinrich,Thomas Krannich,Annkatrin Bressin,Michaela F. Hartmann,Stefan A. Wudy,Dina K. N. Dechmann,Dina K. N. Dechmann,Alicia Hurtado,Francisco J. Barrionuevo,Magdalena Schindler,Magdalena Schindler,Izabela Harabula,Marco Osterwalder,Marco Osterwalder,Michael Hiller,Lars Wittler,Axel Visel,Axel Visel,Axel Visel,Bernd Timmermann,Axel Meyer,Martin Vingron,Rafael Jiménez,Stefan Mundlos,Stefan Mundlos,Darío G. Lupiáñez +36 more
TL;DR: Phylogenomic analyses identify altered regulation at the CYP17A1 and FGF9 loci that contribute to ovotestis formation in moles and highlight how integrative genomic approaches can reveal the phenotypic impact of noncoding sequence changes.
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A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging.
Bernd Timmermann,Stefanie Jarolim,Hannes Russmayer,Martin Kerick,Steve Michel,Antje Krüger,Katharina Bluemlein,Peter Laun,Johannes Grillari,Hans Lehrach,Michael Breitenbach,Markus Ralser +11 more
TL;DR: This study shows that the re-sequencing of entire genomes is becoming a promising alternative for the identification of functional alleles in approaches of classic molecular genetics.
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The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo
TL;DR: This analysis provides the first complete transcriptome data for the mouse embryo and offers a rich data source for the analysis of individual genes and gene regulatory networks controlling mid-gestational development.