B
Bettina Linnartz-Gerlach
Researcher at University of Bonn
Publications - 15
Citations - 940
Bettina Linnartz-Gerlach is an academic researcher from University of Bonn. The author has contributed to research in topics: Microglia & SIGLEC. The author has an hindex of 13, co-authored 15 publications receiving 761 citations. Previous affiliations of Bettina Linnartz-Gerlach include University Hospital Bonn.
Papers
More filters
Journal ArticleDOI
Neurodegeneration by Activation of the Microglial Complement–Phagosome Pathway
Liviu-Gabriel Bodea,Yiner Wang,Bettina Linnartz-Gerlach,Jens Kopatz,Lasse Sinkkonen,Ruth E. Musgrove,Tony Kaoma,Arnaud Muller,Laurent Vallar,Donato A. Di Monte,Rudi Balling,Harald Neumann +11 more
TL;DR: It is demonstrated in vivo that repeated systemic challenge of mice over four consecutive days with bacterial LPS maintained an elevated microglial inflammatory phenotype and induced loss of dopaminergic neurons in the substantia nigra, confirming the involvement of the complement system in neurodegeneration.
Journal ArticleDOI
Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.
Matthias W. Sieber,Nadine Jaenisch,Martin Brehm,Madlen Guenther,Bettina Linnartz-Gerlach,Harald Neumann,Otto W. Witte,Christiane Frahm +7 more
TL;DR: It is concluded that TREM2 appears to sustain a distinct inflammatory response after stroke, and a contradictory scenario that the sub-acute inflammatory reaction after stroke is attenuated in TREM 2-KO mice is supported.
Journal ArticleDOI
CXCL10 Triggers Early Microglial Activation in the Cuprizone Model
Tim Clarner,Katharina Janssen,Lara Nellessen,Martin Stangel,Thomas Skripuletz,Barbara Krauspe,Franz-Martin Hess,Bernd Denecke,Clara Beutner,Bettina Linnartz-Gerlach,Harald Neumann,Luc Vallières,Sandra Amor,Kim Ohl,Klaus Tenbrock,Cordian Beyer,Markus Kipp +16 more
TL;DR: The cuprizone model is used to investigate the temporal and causal relationship of oligodendrocyte apoptosis and early microglia activation and shows that CXCL10 actively participates in the initiation of microglial activation.
Journal ArticleDOI
Unique transcriptome signature of mouse microglia.
Clara Beutner,Bettina Linnartz-Gerlach,Susanne Schmidt,Marc Beyer,Michael R. Mallmann,Andrea Staratschek-Jox,Joachim L. Schultze,Harald Neumann +7 more
TL;DR: Assessment of genome‐wide transcriptional regulation demonstrates that microglial cells are unique and clearly distinct from other macrophage cell types.
Journal ArticleDOI
Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst
TL;DR: Data suggest that Siglec-E recognizes the intact neuronal glycocalyx and has neuroprotective function by preventing phagocytosis and the associated oxidative burst.