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Beverly L. Davidson
Researcher at Children's Hospital of Philadelphia
Publications - 410
Citations - 35019
Beverly L. Davidson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Gene silencing & RNA interference. The author has an hindex of 94, co-authored 391 publications receiving 33041 citations. Previous affiliations of Beverly L. Davidson include United States Department of Veterans Affairs & University of California, Los Angeles.
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RNA polymerase III transcribes human microRNAs
TL;DR: The genomic analysis of miRNAs in the human chromosome 19 miRNA cluster (C19MC) revealed that they are interspersed among Alu repeats, and these findings extend the current view of miRNA origins and the transcriptional machinery driving their expression.
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Transvascular delivery of small interfering RNA to the central nervous system
Priti Kumar,Haoquan Wu,Jodi L. McBride,Kyeong Eun Jung,Moon Hee Kim,Beverly L. Davidson,Sang-Kyung Lee,Premlata Shankar,N. Manjunath +8 more
TL;DR: RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier and afforded robust protection against fatal viral encephalitis in mice.
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siRNA-mediated gene silencing in vitro and in vivo
TL;DR: A viral-mediated delivery mechanism that results in specific silencing of targeted genes through expression of small interfering RNA (siRNA) is described, establishing proof of principle by markedly diminishing expression of exogenous and endogenous genes in vitro and in vivo in brain and liver.
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Lysosomal storage diseases
TL;DR: Lysosomal storage diseases (LSDs) are a group of over 70 diseases characterized by lysosome dysfunction, most of which are inherited as autosomal recessive traits.
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A model system for in vivo gene transfer into the central nervous system using an adenoviral vector.
TL;DR: A model system of direct gene transfer using a replication–defective adenoviral vector containing a β–galactosidase gene to transduce brain neurons is developed, suggesting an attractive and efficient alternative for neuronal gene transfer in vivo.