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Biliana Marcheva
Researcher at Northwestern University
Publications - 23
Citations - 4494
Biliana Marcheva is an academic researcher from Northwestern University. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 15, co-authored 20 publications receiving 3812 citations. Previous affiliations of Biliana Marcheva include NorthShore University HealthSystem.
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Journal ArticleDOI
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Biliana Marcheva,Kathryn Moynihan Ramsey,Ethan D. Buhr,Yumiko Kobayashi,Hong Su,Caroline H. Ko,Ganka Ivanova,Chiaki Omura,Shelley Mo,Martha Hotz Vitaterna,James P. Lopez,Louis H. Philipson,Christopher A. Bradfield,Seth D. Crosby,Lellean JeBailey,Xiaozhong Wang,Joseph S. Takahashi,Joseph Bass +17 more
TL;DR: A role for the β-cell clock is demonstrated in coordinating insulin secretion with the sleep–wake cycle, and ablation of the pancreatic clock can trigger the onset of diabetes mellitus.
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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis
Kathryn Moynihan Ramsey,Jun Yoshino,Cynthia S. Brace,Dana Abrassart,Yumiko Kobayashi,Yumiko Kobayashi,Biliana Marcheva,Hee Kyung Hong,Jason L. Chong,Ethan D. Buhr,Choogon Lee,Joseph S. Takahashi,Shin-ichiro Imai,Joseph Bass,Joseph Bass +14 more
TL;DR: It is reported that both the rate-limiting enzyme in mammalian Nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice.
Journal ArticleDOI
Circadian rhythms, sleep, and metabolism
TL;DR: How investigation of molecular timing may create new opportunities to understand and develop therapies for obesity and diabetes is evaluated.
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Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Clara Bien Peek,Alison H. Affinati,Kathryn Moynihan Ramsey,Hsin Yu Kuo,Hsin Yu Kuo,Wei Yu,Laura A. Sena,Olga Ilkayeva,Biliana Marcheva,Yumiko Kobayashi,Chiaki Omura,Daniel C. Levine,David J. Bacsik,David Gius,Christopher B. Newgard,Eric S. Goetzman,Navdeep S. Chandel,John M. Denu,Milan Mrksich,Milan Mrksich,Joseph Bass +20 more
TL;DR: The results show that the circadian clock generates oscillations in mitochondrial oxidative capacity through rhythmic regulation of NAD+ biosynthesis, and facilitates oxidative rhythms that correspond with the fasting-feeding cycle to maximize energy production during rest.
Journal ArticleDOI
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Mark Perelis,Biliana Marcheva,Kathryn Moynihan Ramsey,Matthew J. Schipma,Alan L. Hutchison,Akihiko Taguchi,Clara Bien Peek,Hee Kyung Hong,Wenyu Huang,Chiaki Omura,Amanda L. Allred,Christopher A. Bradfield,Aaron R. Dinner,Grant D. Barish,Joseph Bass +14 more
TL;DR: A transcriptional process through which the core clock aligns physiology with the light cycle is uncovered, revealing pathways that are important in both health and disease states such as type 2 diabetes.