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Kathryn Moynihan Ramsey
Researcher at Northwestern University
Publications - 40
Citations - 7222
Kathryn Moynihan Ramsey is an academic researcher from Northwestern University. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 22, co-authored 36 publications receiving 6078 citations. Previous affiliations of Kathryn Moynihan Ramsey include NorthShore University HealthSystem & Washington University in St. Louis.
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Journal ArticleDOI
High-fat diet disrupts behavioral and molecular circadian rhythms in mice.
Akira Kohsaka,Aaron D. Laposky,Kathryn Moynihan Ramsey,Kathryn Moynihan Ramsey,Carmela Estrada,Corinne E. Joshu,Yumiko Kobayashi,Fred W. Turek,Joseph Bass +8 more
TL;DR: It is shown that a high-fat diet in mice leads to changes in the period of the locomotor activity rhythm and alterations in the expression and cycling of canonical circadian clock genes, nuclear receptors that regulate clock transcription factors, and clock-controlled genes involved in fuel utilization in the hypothalamus, liver, and adipose tissue.
Journal ArticleDOI
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Biliana Marcheva,Kathryn Moynihan Ramsey,Ethan D. Buhr,Yumiko Kobayashi,Hong Su,Caroline H. Ko,Ganka Ivanova,Chiaki Omura,Shelley Mo,Martha Hotz Vitaterna,James P. Lopez,Louis H. Philipson,Christopher A. Bradfield,Seth D. Crosby,Lellean JeBailey,Xiaozhong Wang,Joseph S. Takahashi,Joseph Bass +17 more
TL;DR: A role for the β-cell clock is demonstrated in coordinating insulin secretion with the sleep–wake cycle, and ablation of the pancreatic clock can trigger the onset of diabetes mellitus.
Journal ArticleDOI
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis
Kathryn Moynihan Ramsey,Jun Yoshino,Cynthia S. Brace,Dana Abrassart,Yumiko Kobayashi,Yumiko Kobayashi,Biliana Marcheva,Hee Kyung Hong,Jason L. Chong,Ethan D. Buhr,Choogon Lee,Joseph S. Takahashi,Shin-ichiro Imai,Joseph Bass,Joseph Bass +14 more
TL;DR: It is reported that both the rate-limiting enzyme in mammalian Nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice.
Journal ArticleDOI
Circadian rhythms, sleep, and metabolism
TL;DR: How investigation of molecular timing may create new opportunities to understand and develop therapies for obesity and diabetes is evaluated.
Journal ArticleDOI
Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Clara Bien Peek,Alison H. Affinati,Kathryn Moynihan Ramsey,Hsin Yu Kuo,Hsin Yu Kuo,Wei Yu,Laura A. Sena,Olga Ilkayeva,Biliana Marcheva,Yumiko Kobayashi,Chiaki Omura,Daniel C. Levine,David J. Bacsik,David Gius,Christopher B. Newgard,Eric S. Goetzman,Navdeep S. Chandel,John M. Denu,Milan Mrksich,Milan Mrksich,Joseph Bass +20 more
TL;DR: The results show that the circadian clock generates oscillations in mitochondrial oxidative capacity through rhythmic regulation of NAD+ biosynthesis, and facilitates oxidative rhythms that correspond with the fasting-feeding cycle to maximize energy production during rest.