Laura A. Sena

TL;DR: More and more evidence suggests that mROS are critical for healthy cell function, and this evidence is discussed following some background on the generation and regulation ofmROS.

TL;DR: It is shown that mitochondrial metabolism in the absence of glucose metabolism is sufficient to support interleukin-2 (IL-2) induction and mitochondria are required for T cell activation to produce mROS for activation of nuclear factor of activated T cells (NFAT) and subsequent IL-2 induction.

TL;DR: The evidence and mechanisms that mitochondrial dependent signaling controls innate and adaptive immune responses are discussed.

TL;DR: The results show that the circadian clock generates oscillations in mitochondrial oxidative capacity through rhythmic regulation of NAD+ biosynthesis, and facilitates oxidative rhythms that correspond with the fasting-feeding cycle to maximize energy production during rest.

TL;DR: Treg cell-specific ablation of mitochondrial respiratory chain complex III in mice results in the development of fatal inflammatory disease early in life, without affecting Treg cell number.