B
Bing-Wen Soong
Researcher at Taipei Veterans General Hospital
Publications - 144
Citations - 5378
Bing-Wen Soong is an academic researcher from Taipei Veterans General Hospital. The author has contributed to research in topics: Spinocerebellar ataxia & Ataxia. The author has an hindex of 39, co-authored 141 publications receiving 4776 citations. Previous affiliations of Bing-Wen Soong include Taipei Medical University & National Institutes of Health.
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Journal ArticleDOI
FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS
Ching-Paio Tsai,Ching-Paio Tsai,Bing-Wen Soong,Bing-Wen Soong,Kon-Ping Lin,Kon-Ping Lin,Pang-Hsien Tu,Jer-Li Lin,Yi-Chung Lee,Yi-Chung Lee +9 more
TL;DR: This study defined the distribution and frequency of mutations of FALS in a Taiwanese Han Chinese population, which not only broadens the spectrum of the mutations causing FALS, but also further highlights the importance of FUS and TARDBP in the pathogenesis of amyotrophic lateral sclerosis.
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Characterization of CADASIL among the Han Chinese in Taiwan: Distinct genotypic and phenotypic profiles
Yi-Chu Liao,Cheng-Tsung Hsiao,Jong Ling Fuh,Chang-Ming Chern,Wei Ju Lee,Yuh-Cherng Guo,Shuu Jiun Wang,I-Hui Lee,Yo-Tsen Liu,Yen-Feng Wang,Feng Chi Chang,Ming-Hung Chang,Bing-Wen Soong,Yi-Chung Lee +13 more
TL;DR: The present study broadens the spectrum of NOTCH3 mutations and provides additional insights for the clinical and molecular characteristics of CADASIL patients of Han-Chinese descents.
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A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy.
Pei-Chien Tsai,Bing-Wen Soong,Inès Mademan,Inès Mademan,Yen Hua Huang,Chia Rung Liu,Cheng Tsung Hsiao,Hung Ta Wu,Tze Tze Liu,Yo Tsen Liu,Yen Ting Tseng,Kon Ping Lin,Ueng Cheng Yang,Ki Wha Chung,Byung Ok Choi,Garth A. Nicholson,Marina L. Kennerson,Chih-Chiang Chan,Peter De Jonghe,Peter De Jonghe,Tzu Hao Cheng,Yi-Chu Liao,Stephan Züchner,Jonathan Baets,Jonathan Baets,Yi-Chung Lee +25 more
TL;DR: Findings establish WARS as a gene whose mutations may cause distal hereditary motor neuropathy and alter canonical and non-canonical functions of TrpRS.
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Asian Origin for the Worldwide-Spread Mutational Event in Machado-Joseph Disease
Sandra Martins,Francesc Calafell,Claudia Gaspar,Virginia Wong,Isabel Silveira,Garth A. Nicholson,Ewout R. Brunt,Lisbeth Tranebjærg,Giovanni Stevanin,Mingli Hsieh,Bing-Wen Soong,Leal Loureiro,Alexandra Durr,Shoji Tsuji,Mitsunori Watanabe,Laura Bannach Jardim,Paola Giunti,Olaf Riess,Laura P.W. Ranum,Alexis Brice,Guy A. Rouleau,Paula Coutinho,António Amorim,Jorge Sequeiros +23 more
TL;DR: The worldwide-spread mutation may have first occurred in Asia and later been diffused throughout Europe, with a founder effect accounting for its high prevalence in Portugal; the other Machado-Joseph disease lineage is more recent, about 1416 +/- 434 years old, and its dispersion may be explained mainly by recent Portuguese emigration.
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Transient Global Amnesia: Cerebral Venous Outflow Impairment-Insight from the Abnormal Flow Patterns of the Internal Jugular Vein
TL;DR: Findings suggest that transient global amnesia might be one of the clinical manifestations of the "cerebral-type intermittent venous claudication," which stems from cerebral venous outflow impairment, insufficient venous collaterals and specific precipitating factors.