Y
Yali Dou
Researcher at University of Michigan
Publications - 80
Citations - 8884
Yali Dou is an academic researcher from University of Michigan. The author has contributed to research in topics: Histone methyltransferase & Histone methylation. The author has an hindex of 37, co-authored 69 publications receiving 7889 citations. Previous affiliations of Yali Dou include Rockefeller University.
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Journal ArticleDOI
Human PAD4 regulates histone arginine methylation levels via demethylimination.
Yanming Wang,Joanna Wysocka,Joyce Sayegh,Youngho Lee,Julie R. Perlin,Lauriebeth Leonelli,Lakshmi S. Sonbuchner,Charles H. McDonald,Richard G. Cook,Yali Dou,Robert G. Roeder,Steven Clarke,Michael R. Stallcup,C. David Allis,Scott A. Coonrod +14 more
TL;DR: It is demonstrated that human peptidylarginine deiminase 4 (PAD4) regulates histone Arg methylation by converting methyl-Arg to citrulline and releasing methylamine, and that PAD4 activity is linked with the transcriptional regulation of estrogen-responsive genes in MCF-7 cells.
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WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development
Joanna Wysocka,Tomek Swigut,Thomas A. Milne,Yali Dou,Xin Zhang,Alma L. Burlingame,Robert G. Roeder,Ali H. Brivanlou,C. David Allis +8 more
TL;DR: The results are the first demonstration that a WD40-repeat protein acts as a module for recognition of a specific histone modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation.
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Regulation of MLL1 H3K4 methyltransferase activity by its core components
Yali Dou,Thomas A. Milne,Alexander J. Ruthenburg,Alexander J. Ruthenburg,Seunghee Lee,Jae Woon Lee,Gregory L. Verdine,C. David Allis,Robert G. Roeder +8 more
TL;DR: This study reports the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex and demonstrates that WDR5 mediates interactions of the MLL1 catalytic unit both with the common structural platform and with the histone substrate.
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Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF
Yali Dou,Thomas A. Milne,Thomas A. Milne,Alan J. Tackett,Edwin R. Smith,Aya Fukuda,Joanna Wysocka,C. David Allis,Brian T. Chait,Jay L. Hess,Robert G. Roeder +10 more
TL;DR: An activator-based mechanism for joint MLL1 and MOF recruitment and targetedmethylation and acetylation is indicated and a molecular explanation for the closely correlated distribution of H3 K4 methylation and H4 K16 acetylations on active genes is provided.
Journal ArticleDOI
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
Thomas A. Milne,Christina M. Hughes,Ricardo V. Lloyd,Zhaohai Yang,Orit Rozenblatt-Rosen,Yali Dou,Robert W. Schnepp,Cynthia Krankel,Virginia A. LiVolsi,Denise Gibbs,Xianxin Hua,Robert G. Roeder,Matthew Meyerson,Jay L. Hess +13 more
TL;DR: It is shown that menin directly regulates expression of the cyclin-dependent kinase inhibitors p27Kip1 and p18Ink4c and plays a central role in menin's activity as a tumor suppressor.