B
Blanche Woehl
Researcher at Garvan Institute of Medical Research
Publications - 3
Citations - 733
Blanche Woehl is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: B-cell activating factor & Receptor. The author has an hindex of 3, co-authored 3 publications receiving 689 citations.
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Journal ArticleDOI
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
Frederic Sierro,Christine Biben,Laura Martínez-Muñoz,Mario Mellado,Richard M. Ransohoff,Meizhang Li,Blanche Woehl,Helen Leung,Joanna R Groom,Marcel Batten,Richard P. Harvey,Carlos Martínez-A,Charles R. Mackay,Fabienne Mackay +13 more
TL;DR: A specialized role for CxCR7 in endothelial biology and valve development is revealed and the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CX CR4 is highlighted.
Journal ArticleDOI
BAFF costimulation of Toll-like receptor-activated B-1 cells
Lai Guan Ng,Lai Guan Ng,Chee-Hoe Ng,Blanche Woehl,Andrew P. R. Sutherland,Jianxin Huo,Shengli Xu,Fabienne Mackay,Kong-Peng Lam +8 more
TL;DR: It is shown that BAFF treatment of B‐1 cells leads to increased NF‐κB p100 processing and CD21/CD35 expression, and toll‐like receptor (TLR) engagement of B-1 cells augmented the surface expression of BAFF receptors and rendered them responsive to BAFF costimulation, providing evidence that BAff plays a role in innate immunity.
Journal ArticleDOI
Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice.
Carrie A. Fletcher,Joanna R Groom,Blanche Woehl,Helen Leung,Charles R. Mackay,Fabienne Mackay,Fabienne Mackay +6 more
TL;DR: The spleen is dispensable for the development of autoimmune nephritis in BAFF Tg mice and points toward a pathogenic role for innate B1 B cells, as well as the possibility of more targeted B cell therapies in humans.