S
Shengli Xu
Researcher at Agency for Science, Technology and Research
Publications - 61
Citations - 3208
Shengli Xu is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Medicine & B cell. The author has an hindex of 23, co-authored 46 publications receiving 2776 citations. Previous affiliations of Shengli Xu include National University of Singapore & Institute of Molecular and Cell Biology.
Papers
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Journal ArticleDOI
TACI and BAFF-R mediate isotype switching in B cells.
Emanuela Castigli,Stephen A. Wilson,Sumi Scott,Fatma Dedeoglu,Shengli Xu,Kong-Peng Lam,Richard J. Bram,Haifa H. Jabara,Raif S. Geha +8 more
TL;DR: The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.
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Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.
Micah J. Benson,Stacey R. Dillon,Emanuela Castigli,Raif S. Geha,Shengli Xu,Kong-Peng Lam,Randolph J. Noelle +6 more
TL;DR: It is reported herein that long-lived BMEM cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand), and BMEM cells represent the only mature B2 lineage subset whose survival is independent of these ligands.
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B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses.
Shengli Xu,Kong-Peng Lam +1 more
TL;DR: A functional redundancy of BCMA in B-cell physiology is suggested that is probably due to the presence of TACI, another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL.
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RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
TL;DR: It is demonstrated that the intracellular RNA virus sensors (RIG-I, MDA5 and TLR3) are activated upon DV infection and are essential for host defense against the virus.
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Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+ Flux and Cytokine Production in Dendritic Cells
TL;DR: It is demonstrated here that stimulation of DCs with zymosan triggers an intracellular Ca2+ flux that can be attenuated by a blocking anti-Dectin-1 antibody or by pre-treatment of cells with the phospholipase C (PLC) γ-inhibitor U73122, suggesting that DectIn-1 signals via a PLCγ pathway to induce Ca1+ flux in DCs.