L
Lu Zhang
Researcher at University of North Carolina at Chapel Hill
Publications - 15
Citations - 4093
Lu Zhang is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Innate immune system & Interferon. The author has an hindex of 10, co-authored 13 publications receiving 3443 citations. Previous affiliations of Lu Zhang include Duke University & Wuhan University.
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Journal ArticleDOI
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Haitao Wen,Denis Gris,Yu Lei,Sushmita Jha,Lu Zhang,Max Tze Han Huang,Willie June Brickey,Jenny P.-Y. Ting +7 more
TL;DR: It is shown that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production, which affects insulin sensitivity through tumor necrosis factor–independent and dependent pathways.
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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Bo Zhong,Yan Yang,Shu Li,Yan-Yi Wang,Ying Li,Feici Diao,Cao-Qi Lei,Xiao He,Lu Zhang,Po Tien,Hong-Bing Shu +10 more
TL;DR: The results suggest that MITA is a critical mediator of virus-triggered IRF3 activation and IFN expression and further demonstrate the importance of certain mitochondrial proteins in innate antiviral immunity.
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The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
Bo Zhong,Lu Zhang,Cao-Qi Lei,Ying Li,Ai-Ping Mao,Yan Yang,Yan-Yi Wang,Xiao-Lian Zhang,Hong-Bing Shu +8 more
TL;DR: It is shown that the E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner and found that virus-induced ubiquitination and degradation of MITA by R NF5 occurred at the mitochondria.
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The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
Monika Schneider,Albert G. Zimmermann,Reid A. Roberts,Lu Zhang,Karen V. Swanson,Haitao Wen,Beckley K. Davis,Beckley K. Davis,Irving C. Allen,Eda K. Holl,Eda K. Holl,Zhengmao Ye,Zhengmao Ye,Adeeb H. Rahman,Adeeb H. Rahman,Brian J. Conti,Brian J. Conti,Timothy K. Eitas,Beverly H. Koller,Jenny P.-Y. Ting +19 more
TL;DR: It is found that NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the transcription factor NF-κB by interacting with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAf6 and activation of NF-σκB.
Journal ArticleDOI
The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy
Yu Lei,Haitao Wen,Yanbao Yu,Debra J. Taxman,Lu Zhang,Douglas G. Widman,Karen V. Swanson,Kwun Wah Wen,Blossom Damania,Christopher Brooks Moore,Patrick M. Giguère,David P. Siderovski,John Hiscott,Babak Razani,Clay F. Semenkovich,Xian Chen,Jenny P.-Y. Ting +16 more
TL;DR: This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM, which has similar functions as NLRX1 by inhibiting RLR-induced IFN-I but promoting autophagy.