B
Bo Lu
Researcher at Ohio State University
Publications - 390
Citations - 24905
Bo Lu is an academic researcher from Ohio State University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 58, co-authored 353 publications receiving 21823 citations. Previous affiliations of Bo Lu include Wuhan University of Technology & Wuhan University.
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Switch Between Apoptosis and Autophagy: Radiation-Induced Endoplasmic Reticulum Stress?
TL;DR: The main molecular mediators that control cellular “switches” between apoptosis and autophagy pathways are summarized by utilizing radiation therapy as a model.
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Integrin αvβ3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non–small-cell lung cancer models
TL;DR: It is concluded that radiation induces expression of α v β 3 integrin in endothelial and non–small-cell lung cancer models, and that integrin antagonist Cilengitide is a radiosensitizer in proportion to the levels of target integrin expression.
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Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy.
TL;DR: The pathways linking autophagy and cancer that are relevant for target identification and on pharmaceuticals that can be utilized to improve cancer therapy by targeting the autophagic pathway are focused on.
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Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2α in caspase-3/7-deficient cells
TL;DR: The mechanism by which radiation triggers autophagy in caspase-3/7-deficient cells is investigated, and the involvement of endoplasmic reticulum (ER) stress is found, revealing ER stress as a novel potential mechanism of radiation-induced autophileagy and as a potential strategy to maximize efficiency of radiation therapy in breast cancer.
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Using Propensity Score Subclassification for Multiple Treatment Doses to Evaluate a National Antidrug Media Campaign
TL;DR: This work extends that of previous authors to subclassification on the propensity score for observational studies with multiple treatment doses, rather than matching onThe propensity score, and proposes modifications to accommodate complex survey data.