B
Bo Lu
Researcher at Ohio State University
Publications - 390
Citations - 24905
Bo Lu is an academic researcher from Ohio State University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 58, co-authored 353 publications receiving 21823 citations. Previous affiliations of Bo Lu include Wuhan University of Technology & Wuhan University.
Papers
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Journal ArticleDOI
Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling.
Hui Wang,Bo Lu,Johnny Castillo,Yue Zhang,Zinger Yang,Gregory McAllister,Alicia Lindeman,John S. Reece-Hoyes,John A. Tallarico,Carsten Russ,Greg Hoffman,Wenqing Xu,Markus Schirle,Feng Cong +13 more
TL;DR: The data suggest that tankyrase inhibition could serve as a novel strategy to suppress YAP signaling for combinatorial targeted therapy.
Journal ArticleDOI
USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
Lei Ji,Bo Lu,Raffaella Zamponi,Olga Charlat,Robert J. Aversa,Zinger Yang,Frederic Sigoillot,Xiaoping Zhu,Tiancen Hu,John S. Reece-Hoyes,Carsten Russ,Gregory A. Michaud,Jan S. Tchorz,Xiaomo Jiang,Feng Cong +14 more
TL;DR: This study reveals a critical mechanism that prevents excessive degradation of Axin and identifies USP7 as a target for sensitizing cells to Wnt/β-catenin signaling through CRISPR screens.
Journal ArticleDOI
Calibration of a novel four-dimensional diode array.
TL;DR: With the proposed calibration method and the automatic gantry angle derivation algorithm, the 4D diode array achieved isotropic detector response and is suitable for both IMRT and rotational therapy pretreatment verification.
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Role of Insulin-Like Growth Factor-1 Signaling Pathway in Cisplatin-Resistant Lung Cancer Cells
Yunguang Sun,Siyuan Zheng,Artour Torossian,Christina K. Speirs,Stephen M. Schleicher,Nicholas J. Giacalone,David P. Carbone,Zhongming Zhao,Bo Lu +8 more
TL;DR: The IGF-1 signaling pathway contributes to cisplatin-R to cis platin and radiation and represents a potential target for improved lung cancer response to treatment, according to microarray expression analysis.
Journal ArticleDOI
PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase
Yi He Ling,Miguel Aracil,Yiyu Zou,Ziqiang Yuan,Bo Lu,J. Jimeno,Ana Maria Cuervo,Roman Perez-Soler +7 more
TL;DR: It is indicated that PM02734 causes cell death by a complex mechanism that involves increased autophagosome content, due for the most part to impairment of autophagic flux, inhibition of the Akt/mTOR pathway, and activation of DAPK.