B
Bo Lu
Researcher at Ohio State University
Publications - 390
Citations - 24905
Bo Lu is an academic researcher from Ohio State University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 58, co-authored 353 publications receiving 21823 citations. Previous affiliations of Bo Lu include Wuhan University of Technology & Wuhan University.
Papers
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Journal ArticleDOI
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.
Hao Zeng,Johnny Castillo-Cabrera,Mika Manser,Bo Lu,Zinger Yang,Vaik Strande,Damien Begue,Raffaella Zamponi,Shumei Qiu,Frederic Sigoillot,Qiong Wang,Alicia Lindeman,John S. Reece-Hoyes,Carsten Russ,Debora Bonenfant,Xiaomo Jiang,Youzhen Wang,Feng Cong +17 more
TL;DR: A genome-wide CRISPR-Cas9 screening uncovered a spectrum of previously unidentified regulators of EGFR TKI sensitivity in EGFR-mutant human NSCLC, providing insights into the heterogeneity of EGfr TKI treatment responses.
Journal ArticleDOI
Decreased Survival After Combining Thoracic Irradiation and an Anti-PD-1 Antibody Correlated With Increased T-cell Infiltration Into Cardiac and Lung Tissues.
Carey J. Myers,Bo Lu +1 more
TL;DR: Combining anti-PD-1 treatment and thoracic radiation has potential for improving the outcomes of locally advanced lung cancer over traditional chemoradiation regimens, but the effect of combining these therapies on non-malignant lung tissue has not yet been investigated in preclinical models.
Journal ArticleDOI
Galactosyl conjugated N-succinyl-chitosan-graft-polyethylenimine for targeting gene transfer
TL;DR: NSC-g-PEI-LA has the potential to be used as a safe and effective targeting gene vector with hepatocyte targeting properties and has a lower cytotoxicity than PEI and the toxicity decreased with increasing substitution of LA.
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ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma
Nicholas J. Giacalone,Robert B. Den,Rosana Eisenberg,Heidi Chen,Sandra J. Olson,Pierre P. Massion,David P. Carbone,Bo Lu,Bo Lu +8 more
TL;DR: For patients with NSCLC, low ALDH7A1 expression was associated with a decreased incidence of cancer recurrence and improved recurrence-free and overall survival, suggesting a predictive role in surgically treated patients.
Journal Article
Receptor tyrosine kinase inhibitors as anti-angiogenic agents.
TL;DR: Preclinical and clinical data from representative anti-angiogenic RTK inhibitors will be discussed in this review.